The effects of closed-loop auditory stimulation on sleep oscillatory dynamics in relation to motor procedural memory consolidation.
The effects of closed-loop auditory stimulation on sleep oscillatory dynamics in relation to motor procedural memory consolidation.
复制标题
闭环听觉刺激对与运动程序记忆巩固相关的睡眠振荡动力学的影响。
DOI：
10.1093/sleep/zsad206
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发表时间：
2023
期刊：
影响因子：
5.6
通讯作者：
Manoach,DaraS
中科院分区：
文献类型：
--
作者：
Baxter,BryanS;Mylonas,Dimitrios;Kwok,KristiS;Talbot,ChristineE;Patel,Rudra;Zhu,Lin;Vangel,Mark;Stickgold,Robert;Manoach,DaraS
研究目标健康老龄化和许多疾病表明睡眠依赖性记忆巩固减少以及非快速眼动睡眠振荡的相应改变。然而，睡眠生理学仍然是改善记忆力的一个相对被忽视的目标。我们评估了睡眠期间闭环听觉刺激 (CLASS) 对慢振荡 (SO)、睡眠纺锤波及其耦合的影响，所有这些都与运动程序记忆巩固有关。 方法 20 名健康的年轻人进行了两次午睡：一次在 SO 上状态期间进行听觉刺激，另一次不进行任何刺激。十二人返回第三次小睡，并在与上州有关的不同时间进行刺激。在所有课程中，参与者在小睡前接受运动序列任务训练，并在小睡后进行测试。结果相对于没有刺激的时期，上部刺激会扰乱睡眠并诱发 SO、纺锤体和 SO 耦合纺锤体。当主轴功率低于未能引起振荡的刺激时，成功引起振荡的刺激被传递到接近 SO 北部的峰值处。在不同条件下，参与者在午睡后表现出类似的显着改善，这与 SO 耦合纺锤体的密度相关。 结论 尽管 CLASS 对睡眠生理有很强的影响，但它未能增强运动程序记忆。我们的研究结果提出了克服这种失败的方法，包括更好的声音校准以保持睡眠连续性，以及使用实时预测算法更精确地瞄准 SO 上状态并避免破坏内源性 SO 耦合纺锤体及其助记功能。它们激励 CLASS 的持续开发，作为操纵睡眠振荡动力学和改善记忆的干预措施。
Study ObjectivesHealthy aging and many disorders show reduced sleep-dependent memory consolidation and corresponding alterations in non-rapid eye movement sleep oscillations. Yet sleep physiology remains a relatively neglected target for improving memory. We evaluated the effects of closed-loop auditory stimulation during sleep (CLASS) on slow oscillations (SOs), sleep spindles, and their coupling, all in relation to motor procedural memory consolidation.MethodsTwenty healthy young adults had two afternoon naps: one with auditory stimulation during SO upstates and another with no stimulation. Twelve returned for a third nap with stimulation at variable times in relation to SO upstates. In all sessions, participants trained on the motor sequence task prior to napping and were tested afterward.ResultsRelative to epochs with no stimulation, upstate stimuli disrupted sleep and evoked SOs, spindles, and SO-coupled spindles. Stimuli that successfully evoked oscillations were delivered closer to the peak of the SO upstate and when spindle power was lower than stimuli that failed to evoke oscillations. Across conditions, participants showed similar significant post-nap performance improvement that correlated with the density of SO-coupled spindles.ConclusionsDespite its strong effects on sleep physiology, CLASS failed to enhance motor procedural memory. Our findings suggest methods to overcome this failure, including better sound calibration to preserve sleep continuity and the use of real-time predictive algorithms to more precisely target SO upstates and to avoid disrupting endogenous SO-coupled spindles and their mnemonic function. They motivate continued development of CLASS as an intervention to manipulate sleep oscillatory dynamics and improve memory.