Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study.
Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study.
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DOI：
10.1016/j.joca.2016.03.011
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发表时间：
2016-08
影响因子：
7
通讯作者：
Messier SP
中科院分区：
文献类型：
--
作者：
Loeser RF;Pathmasiri W;Sumner SJ;McRitchie S;Beavers D;Saxena P;Nicklas BJ;Jordan J;Guermazi A;Hunter DJ;Messier SP
Metabolic factors may contribute to osteoarthritis (OA).This study employed metabolomics analyses to determine if differences in metabolite profiles could distinguish people with knee OA who exhibited radiographic progression. Urine samples obtained at baseline and 18 months from overweight and obese adults in the Intensive Diet and Exercise for Arthritis (IDEA) trial were selected from two subgroups (n=22 each) for metabolomics analysis: a group that exhibited radiographic progression (≥ 0.7mm decrease in joint space width, JSW) and an age, gender, and BMI matched group who did not progress (≤0.35mm decrease in JSW). Multivariate analysis methods, including orthogonal partial least square discriminate analysis, were used to identify metabolite profiles that separated progressors and non-progressors. Plasma levels of IL-6 and C-reactive protein were evaluated as inflammatory markers. Multivariate analysis of the binned metabolomics data distinguished progressors from non-progressors. Library matching revealed that glycolate, hippurate, and trigonelline were among the important metabolites for distinguishing progressors from non-progressors at baseline whereas alanine, N,N-dimethyglycine, glycolate, hippurate, histidine, and trigonelline, were among the metabolites that were important for the discrimination at 18 months. In non-progressors, IL-6 decreased from baseline to 18 months while IL-6 was unchanged in progressors; the change over time in IL-6 was significantly different between groups. These findings support a role for metabolic factors in the progression of knee OA and suggest that measurement of metabolites could be useful to predict progression. Further investigation in a larger sample that would include targeted investigation of specific metabolites is warranted.
