No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation
No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation
复制标题
经颅 DLPFC 刺激对内隐任务序列学习和巩固没有影响
作者：
Branislav Savic;D. Cazzoli;R. Müri;B. Meier
背外侧前额叶皮层（DLPFC）的神经刺激可以调节认知任务中的表现。然而，在最近的一项研究中，经颅直流电刺激（tDCS）的DLPFC不影响内隐任务序列学习和巩固的范式，涉及双手反应。由于双手操作增加了半球的同源皮质区域之间的耦合，并且分别刺激左右DLPFC，因此无效结果可能是由于双手设置造成的。本研究的目的是测试在单手设置的顺序学习的神经刺激的效果。为此，进行了两个实验。在实验1中，用tDCS刺激DLPFC。实验2采用经颅磁刺激（TMS）刺激DLPFC。在两个实验中，24小时后测量固结。结果表明，序列学习在所有条件下都存在，但不受刺激的影响。同样，序列学习的巩固在各个阶段都是稳健的，但它不受刺激的影响。这些结果重复并扩展了以前的发现。他们表明，建立tDCS和TMS协议的DLPFC不影响内隐任务序列的学习和巩固。
Neurostimulation of the dorsolateral prefrontal cortex (DLPFC) can modulate performance in cognitive tasks. In a recent study, however, transcranial direct current stimulation (tDCS) of the DLPFC did not affect implicit task sequence learning and consolidation in a paradigm that involved bimanual responses. Because bimanual performance increases the coupling between homologous cortical areas of the hemispheres and left and right DLPFC were stimulated separately the null findings may have been due to the bimanual setup. The aim of the present study was to test the effect of neuro-stimulation on sequence learning in a uni-manual setup. For this purpose two experiments were conducted. In Experiment 1, the DLPFC was stimulated with tDCS. In Experiment 2 the DLPFC was stimulated with transcranial magnetic stimulation (TMS). In both experiments, consolidation was measured 24 hours later. The results showed that sequence learning was present in all conditions and sessions, but it was not influenced by stimulation. Likewise, consolidation of sequence learning was robust across sessions, but it was not influenced by stimulation. These results replicate and extend previous findings. They indicate that established tDCS and TMS protocols on the DLPFC do not influence implicit task sequence learning and consolidation.
影响因子：
14.5
作者：
Hazeltine, E;Grafton, ST;Ivry, R
通讯作者：
Ivry, R
影响因子：
3.7
作者：
Robertson, EM;Tormos, JM;Pascual-Leone, A
通讯作者：
Pascual-Leone, A