MORPHOLOGICAL AND BIOCHEMICAL-CHANGES IN ESCHERICHIA-COLI AFTER EXPOSURE TO CIPROFLOXACIN
MORPHOLOGICAL AND BIOCHEMICAL-CHANGES IN ESCHERICHIA-COLI AFTER EXPOSURE TO CIPROFLOXACIN
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DOI：
10.1093/jac/18.supplement_d.31
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发表时间：
1986-11-01
影响因子：
5.2
通讯作者：
WISE, R
中科院分区：
文献类型：
--
作者：
DIVER, JM;WISE, R
对接触环丙沙星后大肠杆菌KL-16 的形态和生化变化的检查显示出明显的浓度依赖性反应。在接近 MIC 的水平下，观察到广泛的丝状形成，而在最高杀菌浓度下，细胞被拉长，但没有形成丝状。在较高浓度下观察到卵形细胞。一些细胞显示出表面液泡，但未检测到细胞内容物的显着渗漏。丝状形成和空泡形成对环丙沙星诱导的细胞死亡仅产生很小的影响，并且数据表明有两种或多种机制参与环丙沙星的致死作用。
Examination of morphological and biochemical changes inEscherichia coliKL-16 after exposure to ciprofloxacin revealed distinct concentration-dependent responses. At levels close to the MIC extensive filamentation was seen, whereas at the most bactericidal concentration cells were elongated but not filamented. At higher concentrations ovoid cells were seen. Some cells showed surface vacuoles, but no significant leakage of cell contents was detected. Filamentation and vacuolation were shown to make only a minor contribution to ciprofloxacin-induced cell death, and the data indicate that there are two or more mechanisms involved in the lethal action of ciprofloxacin.