Effect of nanoparticle surface charge at the plasma membrane and beyond.
Effect of nanoparticle surface charge at the plasma membrane and beyond.
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DOI:
10.1021/nl101140t
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发表时间:
2010-07-14
期刊:
影响因子:
10.8
通讯作者:
Mukherjee P
中科院分区:
文献类型:
--
作者:
Arvizo RR;Miranda OR;Thompson MA;Pabelick CM;Bhattacharya R;Robertson JD;Rotello VM;Prakash YS;Mukherjee P
Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and non-malignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.
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