The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats
The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats
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DOI：
10.1016/s0165-0270(01)00326-0
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发表时间：
2001-03-30
影响因子：
3
通讯作者：
Whishaw, IQ
中科院分区：
文献类型：
--
作者：
Ballermann, M;Metz, GAS;Whishaw, IQ
熟练的前肢使用已在许多研究中用于检查大鼠的运动系统状态、学习和神经系统损伤的恢复。许多当前熟练的到达模型中的相关测量依赖于端点测量、成功到达的数量或定性测量、执行到达时使用的移动。本研究描述了一种新的到达任务，它允许测量熟练的前肢运动的距离和方向，同时还允许终点和定性测量。动物从透明的有机玻璃盒中穿过小孔，从远离小孔（矩阵）远端和横向排成行的 260 块垂直方向的意大利面片中取出直的、未煮过的意大利面片。通过扩大触及范围，可以获得更多面食。肢体运动、取出的面食块以及取出面食的模式是相关测量。使用对照、背柱损伤和单侧多巴胺耗尽的动物证明了该测试的有效性。该任务使用想要的食物，测试学习和技能、肢体运动范围以及到达不同距离和方向的能力。该任务还可以修改以研究肢体使用的其他特征，包括技能调整、偏侧性和力量。 (C) 2001 Elsevier Science B.V. 保留所有权利。
Skilled forelimb use has been used in many studies to examine motor system status, learning, and recovery from nervous system damage in rats. The dependent measures in many current skilled reaching models rely on endpoint measures, number of successful reaches, or qualitative measures, the movements used in performing a reach. The present study describes a new reaching task, which allows measurement of distance and direction of skilled forelimb movement while also permitting end point and qualitative measurements. Animals reached From a clear Plexiglas box through an aperture to retrieve pieces of straight, uncooked pasta from an array of 260 vertically oriented pieces of pasta arranged in rows distally and laterally away from the aperture (a matrix). By extending the range of a reach, more pasta is obtained. Limb movements, pieces of pasta removed, and the pattern of pasta removal are dependent measures. The usefulness of the test is demonstrated using control, dorsal column lesion, and unilateral dopamine depleted animals. The task uses a desired food, tests learning and skill, the range of limb movement, and the ability to reach for different distances and directions. The task can also be modified to investigate other features of limb use including skill adjustments, laterality, and force. (C) 2001 Elsevier Science B.V. All rights reserved.