Sensitive J-Coupled Metabolite Mapping Using Sel-MQC With Selective Multi-Spin-Echo Readout
Sensitive J-Coupled Metabolite Mapping Using Sel-MQC With Selective Multi-Spin-Echo Readout
复制标题
使用 Sel-MQC 和选择性多自旋回波读数进行灵敏 J 耦合代谢物图谱
DOI：
10.1002/mrm.22108
复制
发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Jakob, Peter M.
中科院分区：
文献类型：
--
作者：
Melkus, Gerd;Moerchel, Philipp;Jakob, Peter M.
选择性多量子相干技术与读取梯度相结合，以加速特定标量耦合代谢物的测量。在高磁场强度（17.6 T）下的实验中比较了使用纯相位编码的定位和使用读取梯度的定位的灵敏度。使用指定分子组的频率选择性重新聚焦来获取选择性多量子相干编辑的代谢物的多个自旋回波。频率选择性重聚焦不影响耦合自旋系统的J调制，并且回波时间不限于1/J的倍数以获取纯同相或反相信号。多个回波可用于加速代谢物成像实验或测量表观横向弛豫T-2。提出了一种简单的相移方案，该方案能够抑制由水共振的多个自旋回波引起的编辑伪影。这些实验在体模上进行，其中乳酸和多不饱和脂肪酸被编辑，并且在体内肿瘤上进行，其中乳酸含量和T-2被成像。当需要快速和灵敏的选择性多量子相干编辑时，该方法特别令人感兴趣，例如，空间三维实验。Magn Reson Med 62：880-887，2009. (C)2009威利-利斯公司
The selective multiple quantum coherence technique is combined with a read gradient to accelerate the measurement of a specific scalar-coupled metabolite. The sensitivities of the localization using pure phase encoding and localization with the read gradient are compared in experiments at high magnetic field strength (17.6 T). Multiple spin-echoes of the selective multiple quantum coherence edited metabolite are acquired using frequency-selective refocusing of the specified molecule group. The frequency-selective refocusing does not affect the J-modulation of a coupled spin system, and the echo time is not limited to a multiple of 1/J to acquire pure in-phase or antiphase signal. The multiple echoes can be used to accelerate the metabolite imaging experiment or to measure the apparent transverse relaxation T-2. A simple phase-shifting scheme is presented, which enables the suppression of editing artifacts resulting from the multiple spin-echoes of the water resonance. The experiments are carried out on phantoms, in which lactate and polyunsaturated fatty acids are edited, and in vivo on tumors, in which lactate content and T-2 are imaged. The method is of particular interest when a fast and sensitive selective multiple quantum coherence editing is necessary, e.g., for spatial three dimensional experiments. Magn Reson Med 62: 880-887, 2009. (C) 2009 Wiley-Liss, Inc.