A new concept of tissue and tumor cell proliferation.
A new concept of tissue and tumor cell proliferation.
复制标题
组织和肿瘤细胞增殖的新概念。
作者：
S. Gelfant
我们提出了一个细胞和组织增殖的模型，该模型基于循环细胞可以在细胞周期的三个点停止：G1早期（被G0屏障阻断）；在G1后期（通过一个G1块）；在G2后期（G2块）。细胞有四大类：循环细胞；非循环g1阻断细胞；非循环g2阻断细胞；非循环G0阻滞细胞。这些代表了培养的相同类型的细胞和体内组织和肿瘤中的潜在增殖池。该模型还包括了其他亚种群的可能性。这些观点得到了来自各种动物、植物和肿瘤组织体内和体外的例子和证据的支持。在此背景下，我们批判性地回顾了大多数当前循环和非循环细胞的概念和方案。我们还提出了一个描述所有四类循环和非循环细胞的起源和募集的方案，在文献思想的支持下，对细胞转化和肿瘤生长有了新的认识，并建立了新的肿瘤动力学反应模型。从推测的角度来看，我们引入了组织和肿瘤作为增殖生态系统的概念，其中各种类型的循环和非循环细胞（包括前多样化亚群）增加了生存价值，也作为一个复杂的适应系统来满足组织或肿瘤的特定增殖需求。
Summary We present a model for cell and tissue proliferation based upon the idea that cycling cells can arrest at three points in the cell cycle: in early G1 (blocked by a G0 barrier); in late G1 (by a G1 block); and in late G2 (by a G2 block). There are four major categories of cells: cycling cells; noncycling G1-blocked cells; noncycling G2-blocked cells; and noncycling G0 blocked cells. These represent the potential proliferating pool in cells of the same type in culture and in tissues and tumors in vivo. The model also includes the possibility of additional subpopulations. The ideas are supported by examples and evidence taken from a wide variety of animal, plant, and tumor tissues in vivo and in vitro. Within this context, we critically review most of the current concepts and schemes of cycling and noncycling cells. We also present a scheme describing the origin and recruitment of all four categories of cycling and noncycling cells, which, with the support of ideas from the literature, leads to new insights regarding cell transformation and tumor growth and to a new tumor kinetic response model. On a speculative note, we introduce the idea of tissues and tumors as proliferate ecosystems, where the various categories of cycling and noncycling cells (including prediversified subpopulations) increase survival value and also serve as a complex adaptive system to fulfill the particular proliferative needs of the tissue or tumor.