Neuropsychological outcomes after Gamma Knife radiosurgery for mesial temporal lobe epilepsy: a prospective multicenter study.
Neuropsychological outcomes after Gamma Knife radiosurgery for mesial temporal lobe epilepsy: a prospective multicenter study.
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DOI：
10.1111/j.1528-1167.2011.02987.x
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发表时间：
2011-05
期刊：
影响因子：
5.6
通讯作者：
Radiosurgery Epilepsy Study Group
中科院分区：
文献类型：
--
作者：
Quigg M;Broshek DK;Barbaro NM;Ward MM;Laxer KD;Yan G;Lamborn K;Radiosurgery Epilepsy Study Group
在一项伽玛刀治疗内侧颞叶癫痫（MTLE）的前瞻性、多中心初步研究中，评估语言、言语记忆、认知效率和心理灵活性、情绪和生活质量（QOL）的结局。随机分为20戈伊和24戈伊两组，各5.5-7.5mL，50%等剂量体积。在术前基线进行神经心理学评估，并在术后12个月和24个月描述平均变化评分。还提供了36个月时的QOL数据。30例患者接受了治疗，26例可用于最终24个月的神经心理学评价。无论是语言（波士顿测验），言语记忆（加州言语学习测验和韦氏记忆量表修订版的逻辑记忆子测验），认知效率和心理灵活性（连线测验），也没有情绪（贝克抑郁量表）与基线不同。QOL评分在24个月和36个月时改善，其中在24个月时达到癫痫缓解的患者占改善的大部分。认知结果、情绪和QOL的一系列变化在MTLE的RS之后是不显著的。RS可提供开放手术的替代方案，特别是在有认知障碍风险或希望非侵入性替代开放手术的患者中。
To assess outcomes of language, verbal memory, cognitive efficiency and mental flexibility, mood, and quality of life (QOL) in a prospective, multicenter pilot study of Gamma Knife radiosurgery (RS) for mesial temporal lobe epilepsy (MTLE). RS, randomized to 20 Gy or 24 Gy comprising 5.5-7.5mL at the 50% isodose volume, was performed on mesial temporal structures of patients with unilateral MTLE. Neuropsychological evaluations were performed at preoperative baseline, and mean change scores were described at 12 and 24 months postoperatively. QOL data were also available at 36 months. 30 patients were treated and 26 were available for the final 24 month neuropsychological evaluation. Neither language (Boston Naming Test), verbal memory (California Verbal Learning Test and Logical Memory subtest of the Wechsler Memory Scale-Revised), cognitive efficiency and mental flexibility (Trail Making Test), nor mood (Beck Depression Inventory) differed from baseline. QOL scores improved at 24 and 36 months, with those patients attaining seizure remission by month 24 accounting for the majority of the improvement. The serial changes in cognitive outcomes, mood, and QOL are unremarkable following RS for MTLE. RS may provide an alternative to open surgery especially in those patients at risk of cognitive impairment or who desire a noninvasive alternative to open surgery.
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影响因子：
9.9
作者：
Chang, E. F.;Quigg, M.;Barbaro, N. M.
通讯作者：
Barbaro, N. M.
影响因子：
11.2
作者：
Helmstaedter, C;Kurthen, M;Elger, CE
通讯作者：
Elger, CE
影响因子：
5.6
作者：
DEVINSKY, O;VICKREY, BG;HAYS, RD
通讯作者：
HAYS, RD
影响因子：
9.9
作者：
Devinsky, O;Barr, WB;Spencer, SS
通讯作者：
Spencer, SS
影响因子：
2.2
作者：
Rheims, Sylvain;Fischer, Catherine;Mauguiere, Francois
通讯作者：
Mauguiere, Francois