Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle
Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle
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DOI：
10.1016/j.biopsycho.2011.10.018
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发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
Baas, Johanna M. P.
中科院分区：
文献类型：
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作者：
Klumpers, Floris;Heitland, Ivo;Baas, Johanna M. P.
5-羟色胺转运体(SERT)在焦虑中起着至关重要的作用。因此，SERT功能的差异似乎构成了焦虑个体差异的重要途径。目前的研究验证了一种假设，即SERT功能的遗传变异与防御的基本反射生理学的变异有关。健康受试者(N=82)被呈现明确指示的电击威胁和安全线索，以诱导强烈的焦虑反应。携带至少一个5-HITLPR多态短等位基因的受试者比长等位基因纯合子受试者表现出更强的恐惧增强惊吓。然而，在威胁抵消后，短等位基因携带者在下调恐惧方面没有表现出缺陷。这些结果表明，SERT功能的自然变化影响防御反应的大小，而不影响对恐惧的调节能力。(C)2011爱思唯尔B.V.保留所有权利。
The serotonin transporter (SERT) plays a crucial role in anxiety. Accordingly, variance in SERT functioning appears to constitute an important pathway to individual differences in anxiety. The current study tested the hypothesis that genetic variation in SERT function is associated with variability in the basic reflex physiology of defense. Healthy subjects (N = 82) were presented with clearly instructed cues of shock threat and safety to induce robust anxiety reactions. Subjects carrying at least one short allele for the 5-HITLPR polymorphism showed stronger fear-potentiated startle compared to long allele homozygotes. However, short allele carriers showed no deficit in the downregulation of fear after the offset of threat. These results suggest that natural variation in SERT function affects the magnitude of defensive reactions while not affecting the capacity for fear regulation. (C) 2011 Elsevier B.V.All rights reserved.