Mismatch negativity (MMN) and sensory auditory processing in children aged 9-12 years presenting with putative antecedents of schizophrenia
Mismatch negativity (MMN) and sensory auditory processing in children aged 9-12 years presenting with putative antecedents of schizophrenia
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DOI：
10.1016/j.ijpsycho.2013.05.008
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发表时间：
2013-09-01
影响因子：
3
通讯作者：
Laurens, Kristin R.
中科院分区：
文献类型：
--
作者：
Bruggemann, Jason M.;Stockill, Helen V.;Laurens, Kristin R.
在精神分裂症高危儿童中识别异常脑功能的标志物可以为早期干预和预防计划提供信息。精神分裂症患者的特征是MMN振幅衰减，这是自动听觉感觉处理的指标。目前的目的是检查儿童谁可能是在精神分裂症的风险增加，由于他们提出的精神分裂症（ASZ）的多个假定的前因是类似的特点是MMN振幅降低，相对于典型的发展（TD）的儿童。EEG记录从22 ASZ和24 TD儿童年龄在9至12岁（年龄，性别和智商匹配）在被动听觉oddball任务（15%的持续时间偏差）。ASz儿童是那些表现出：（1）语言和/或运动发育滞后/问题;（2）临床范围内的社会，情感或行为问题;和（3）精神病样经历的儿童。TD儿童没有前因，也没有精神分裂症谱系障碍的家族史。MMN振幅，但不是潜伏期，在ASz组的额叶部位比TD组显着更大。虽然精神分裂症风险儿童表现出的MMN与他们通常发育的同龄人不同，但它也不同于精神分裂症成人中观察到的MMN振幅降低。这可能反映了精神病发作前驱期的发育和疾病影响。纵向随访是必要的，以建立在高危儿童的MMN的发展轨迹。(C)2013作者Elsevier B.V.出版，保留所有权利。
Identification of markers of abnormal brain function in children at-risk of schizophrenia may inform early intervention and prevention programs. Individuals with schizophrenia are characterised by attenuation of MMN amplitude, which indexes automatic auditory sensory processing. The current aim was to examine whether children who may be at increased risk of schizophrenia due to their presenting multiple putative antecedents of schizophrenia (ASz) are similarly characterised by MMN amplitude reductions, relative to typically developing (TD) children. EEG was recorded from 22 ASz and 24 TD children aged 9 to 12 years (matched on age, sex, and IQ) during a passive auditory oddball task (15% duration deviant). ASz children were those presenting: (1) speech and/or motor development lags/problems; (2) social, emotional, or behavioural problems in the clinical range; and (3) psychotic-like experiences. TD children presented no antecedents, and had no family history of a schizophrenia spectrum disorder. MMN amplitude, but not latency, was significantly greater at frontal sites in the ASz group than in the TD group. Although the MMN exhibited by the children at risk of schizophrenia was unlike that of their typically developing peers, it also differed from the reduced MMN amplitude observed in adults with schizophrenia. This may reflect developmental and disease effects in a pre-prodromal phase of psychosis onset. Longitudinal follow-up is necessary to establish the developmental trajectory of MMN in at-risk children. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.