Self‐Moisturizing Smart Contact Lens Employing Electroosmosis
Self‐Moisturizing Smart Contact Lens Employing Electroosmosis
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DOI：
10.1002/admt.201900889
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发表时间：
2019-11
影响因子：
6.8
通讯作者：
Shinya Kusama;Kaito Sato;S. Yoshida;M. Nishizawa
中科院分区：
文献类型：
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作者：
Shinya Kusama;Kaito Sato;S. Yoshida;M. Nishizawa
隐形眼镜(CLS)可能会导致“干眼综合症”，导致角膜损伤、炎症以及不适感。为了防止干眼，重要的是保持晶状体湿润，并保持晶状体和眼表之间的泪水。在这里，电渗流(EOF)在化学发光中的应用被报道为一种新的抗脱水机制。一种由带电水凝胶制成的CL被用作产生EOF的流体管道。通过改变含有羧基的阴离子单体的组成比，考虑了EOF的生成效率和水凝胶的机械强度，优化了凝胶的电荷密度。通过电导的现场监测和显微镜观察，成功地证明了CL中向上的EOF有效地保持了透镜的湿润。生物兼容电池(镁/氧气电池和果糖/氧气酶电池)安装在CL上，以演示内置电源的智能CL用于EOF自我保湿的可行性。
Contact lenses (CLs) can be a cause of “dry eye syndrome” that can lead to corneal wounds and inflammation as well as a feeling of discomfort. To prevent the dry eye, it is important to keep the lens moist and maintain tears between the CL and the ocular surface. Here, the use of electroosmotic flow (EOF) in a CL is reported as a novel mechanism for antidehydration. A CL made from a charged hydrogel has served as the fluid conduit for EOF generation. The charge density of the gel is optimized by varying the composition ratio of anionic monomer having carboxyl group, by taking into account the efficiency of EOF generation and the mechanical strength of the hydrogels. By in situ monitoring of conductance and by microscope observations, it is successfully demonstrated that the upward EOF within CL is effective to maintain a moist lens. Biocompatible batteries (Mg/O2 battery and fructose/O2 enzymatic battery) are mounted on the CL to demonstrate the feasibility of a smart CL with a built‐in power source for EOF‐based self‐moisturization.