Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?
Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?
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加压素能否维持正常水分充足的健康志愿者的血压？
DOI：
10.1152/ajpheart.1984.246.1.h143
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
H. Brunner
中科院分区：
文献类型：
--
作者：
J. Bussien;B. Waeber;J. Nussberger;M. Schaller;H. Gavras;K. Hofbauer;H. Brunner
精氨酸加压素 (AVP) 的升压作用抑制剂 d(CH2)5Tyr(Me)AVP，静脉注射剂量为 5 微克/kg，在四名健康志愿者中显示，可拮抗赖氨酸加压素输注 1 mIU X kg-1 X min-1 时的血压、心率和皮肤血流反应。抑制作用持续2小时以上。当将相同剂量的加压素拮抗剂给予 10 名健康正常、水分充足的志愿者时，其肾素系统完好或被 25 mg 卡托普利口服严重阻断，上述参数均未发生变化。结论是，即使在肾素-血管紧张素系统受阻的情况下，循环加压素也不会积极促进心血管稳态的维持。
The inhibitor of the pressor effect of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, at a dose of 5 micrograms/kg iv was shown in four healthy volunteers to antagonize the blood pressure, heart rate, and skin blood flow response to a lysine vasopressin infusion of 1 mIU X kg-1 X min-1. The inhibition lasted for more than 2 h. When the same dose of the vasopressin antagonist was administered to 10 healthy normally hydrated volunteers with their renin system intact or acutely blocked by 25 mg of captopril po, none of the above parameters changed. It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis.