Ruthenium-catalysed atom-transfer cyclisation of N-(cyclohex-2-enyl)-α-chloro-α-(phenylthio)acetamides. A formal total synthesis of (±)-haemanthidine and (±)-pretazettine
Ruthenium-catalysed atom-transfer cyclisation of N-(cyclohex-2-enyl)-α-chloro-α-(phenylthio)acetamides. A formal total synthesis of (±)-haemanthidine and (±)-pretazettine
复制标题
钌催化 N-(环己-2-烯基)-α-氯-α-(苯硫基)乙酰胺的原子转移环化(±)-haemanthidine 和 (±)-pretazettine。
DOI：
10.1039/c39890001767
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Ikeda
中科院分区：
文献类型：
--
作者：
H. Ishibashi*;H. Nakatani;S. Iwami;Tatsunori Sato;N. Nakamura;M. Ikeda
氢吲哚（18）以前是（±）-海曼西啶(2)和（±）-pretazettine(1)全合成的关键中间体，通过钌催化α-氯硫化物的原子转移环化反应，以高度立体控制的方式制备。
The hydroindole (18), which previously served as a key intemediate in the total synthesis of (±)-haemanthidine (2) and (±)-pretazettine (1), has been prepared in a highly stereocontrolled manner by a reaction sequence involving a ruthenium-catalysed atom-transfer cyclisation of an α-chloro sulphide.