Gaur genome reveals expansion of sperm odorant receptors in domesticated cattle.

Gaur genome reveals expansion of sperm odorant receptors in domesticated cattle.
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Gaur基因组揭示了驯化牛精子气味受体的扩增。

DOI:
10.1186/s12864-022-08561-1
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发表时间:
2022-05-04
期刊:
影响因子:
4.4
通讯作者:
--
中科院分区:
生物学2区
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野牛(Bos Gaurus)是现存最大的野生牛种,原产于南亚和东南亚,具有独特的特征,被国际自然保护联盟(IUCN)列为脆弱物种。我们报道了第一个GARR参考基因组,并确定了三条生物学途径,包括溶菌酶活性、质子跨膜转运蛋白活性和氧运输,与其他哺乳动物相比,GAR的基因拷贝数发生了显著变化。这些可能反映了对与气候和营养有关的挑战的适应。与驯化的印度牛和牛磺酸牛的比较分析揭示了人工选择的基因组特征,包括家养牛精子气味受体基因的扩展,这可能对理解雄性生育选择具有重要意义。除了帮助解剖重要的经济性状外,Gaur基因组还将为保护该物种提供基础。网上版载有补充材料,可在10.1186/s12864-022-08561-1查阅。
The gaur (Bos gaurus) is the largest extant wild bovine species, native to South and Southeast Asia, with unique traits, and is listed as vulnerable by the International Union for Conservation of Nature (IUCN). We report the first gaur reference genome and identify three biological pathways including lysozyme activity, proton transmembrane transporter activity, and oxygen transport with significant changes in gene copy number in gaur compared to other mammals. These may reflect adaptation to challenges related to climate and nutrition. Comparative analyses with domesticated indicine (Bos indicus) and taurine (Bos taurus) cattle revealed genomic signatures of artificial selection, including the expansion of sperm odorant receptor genes in domesticated cattle, which may have important implications for understanding selection for male fertility. Apart from aiding dissection of economically important traits, the gaur genome will also provide the foundation to conserve the species. The online version contains supplementary material available at 10.1186/s12864-022-08561-1.
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