Docking domains and substrate-specificity determination for MAP kinases
Docking domains and substrate-specificity determination for MAP kinases
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DOI：
10.1016/s0968-0004(00)01627-3
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发表时间：
2000-09-01
影响因子：
13.8
通讯作者：
Galanis, A
中科院分区：
文献类型：
--
作者：
Sharrocks, AD;Yang, SH;Galanis, A
真核细胞中的信号特异性由几种机制维持。丝裂原活化蛋白（MAP）激酶确保其作用特异性的一种机制是通过对接结构域与其底物相互作用。这些对接结构域将激酶募集到正确的底物上，并增强其保真度和作用效率。底物中的其他特异性决定簇用于进一步增强MAP激酶对底物磷酸化的特异性。
Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further.