Deletion/insertion polymorphism in the angiotension-converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease
Deletion/insertion polymorphism in the angiotension-converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease
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DOI：
10.1007/s004240000084
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发表时间：
2000-01-01
影响因子：
4.5
通讯作者：
Keber, I
中科院分区：
文献类型：
--
作者：
Peterlin, B;Petrovic, D;Keber, I
血管紧张素转换酶（ACE）通过降解血管紧张素I和缓激肽，在调节平滑肌增殖和血管张力中发挥重要作用。典型的血浆ACE水平伴随着VD多态性;然而，关于ACE多态性的DD基因型是否影响冠心病（CHD）的发展风险存在争议。我们比较了171名年龄小于55岁的斯洛文尼亚冠心病患者和134名健康对照者的I/D多态性。DD基因型与CHD风险增加2.3倍相关。
The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the VD polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger than 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.