Improvement of general symptoms in a chronic psychotic patient treated with finasteride: Case report
Improvement of general symptoms in a chronic psychotic patient treated with finasteride: Case report
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DOI：
10.1055/s-2008-1058110
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发表时间：
2008-05-01
影响因子：
4.3
通讯作者：
Leweke, F. M.
中科院分区：
文献类型：
--
作者：
Koethe, D.;Bortolato, M.;Leweke, F. M.
& Recent evidence indicates that neuroactive steroids (NS) may participate in the pathogenesis of the schizophrenia spectrum of disorders. NS levels have been correlated to symptom severity in schizophrenic patients [8], and have been shown to influence the function of major key substrates involved in the pathophysiology of psychotic disorders, such as the dopaminergic mes olimbic system [3, 5]. Bortolato et al.[1] investigated the role of 5-reductase (5AR), the rate-limiting enzyme of one of the two major metabolic pathways in brain steroidogenesis, in schizophrenia, suggesting that 5AR inhibitors elicit antipsychotic-like effects in animals.
