INDUCTION OF IMMEDIATE SPATIOTEMPORAL CHANGES IN THALAMIC NETWORKS BY PERIPHERAL BLOCK OF ASCENDING CUTANEOUS INFORMATION
INDUCTION OF IMMEDIATE SPATIOTEMPORAL CHANGES IN THALAMIC NETWORKS BY PERIPHERAL BLOCK OF ASCENDING CUTANEOUS INFORMATION
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DOI：
10.1038/361533a0
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发表时间：
1993-02-11
期刊：
影响因子：
64.8
通讯作者：
CHAPIN, JK
中科院分区：
文献类型：
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作者：
NICOLELIS, MAL;LIN, RCS;CHAPIN, JK
外周感觉剥夺诱导成年动物体感觉皮层内的重组1-6。虽然大多数研究都集中在体感觉皮层1-6上，但皮层下水平（例如丘脑）的变化也可能在感觉可塑性中发挥基本作用7-11。为了研究这一点，我们对成年大鼠丘脑腹侧后内侧（VPM）的大量单个神经元进行了慢性同步记录。这使得在感觉剥夺之前和之后，可以对每只动物的单个VPM神经元的同一样本的接受野进行连续和定量的评估。面部局部麻醉诱导了大部分VPM地图的立即和可逆的重组。这对单个VPM神经元的短潜伏期（4-6 ms）反应和长潜伏期（15-25 ms）反应有不同的影响。slr和llr通常定义了VPM12中时空复杂的感受野。在本研究中，我们报告了73%的原始接受野包括麻醉区的单个神经元，在邻近皮肤区域的刺激下，单面反射区立即被揭开，在麻醉区周围区域的刺激下，单面反射区丢失，而单面反射区保留或增强。这种丘脑重组表明，外周感觉剥夺可能会在体感觉系统的多个层面上引起立即的可塑性变化。此外，其时空复杂性表明，在多个上升和下降影响之间的正常动态平衡被破坏。
PERIPHERAL sensory deprivation induces reorganization within the somatosensory cortex of adult animals1-6. Although most studies have focused on the somatosensory cortex1-6, changes at subcortical levels (for example the thalamus) could also play a fundamental role in sensory plasticity7-11. To investigate this, we made chronic simultaneous recordings of large numbers of single neurons across the ventral posterior medial thalamus (VPM) in adult rats. This allowed a continuous and quantitative evaluation of the receptive fields of the same sample of single VPM neurons per animal, before and after sensory deprivation. Local anaesthesia in the face induced an immediate and reversible reorganization of a large portion of the VPM map. This differentially affected the short latency (4-6 ms) responses (SLRs) and long latency (15-25 ms) responses (LLRs) of single VPM neurons. The SLRs and LLRs normally define spatiotemporally complex receptive fields in the VPM12. Here we report that 73% of single neurons whose original receptive fields included the anaesthetized zone showed immediate unmasking of SLRs in response to stimulation of adjacent cutaneous regions, and/or loss of SLRs with preservation or enhancement of LLRs in response to stimulation of regions just surrounding the anaesthetized zone. This thalamic reorganization demonstrates that peripheral sensory deprivation may induce immediate plastic changes at multiple levels of the somatosensory system. Further, its spatiotemporally complex character suggests a disruption of the normal dynamic equilibrium between multiple ascending and descending influences on the VPM.