ACCUMULATION OF 1,2-DIACYLGLYCEROL IN PLASMA-MEMBRANE MAY LEAD TO ECHINOCYTE TRANSFORMATION OF ERYTHROCYTES
ACCUMULATION OF 1,2-DIACYLGLYCEROL IN PLASMA-MEMBRANE MAY LEAD TO ECHINOCYTE TRANSFORMATION OF ERYTHROCYTES
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DOI：
10.1038/258348a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
MICHELL, RH
中科院分区：
文献类型：
--
作者：
ALLAN, D;MICHELL, RH
红细胞从正常的双凹面圆盘到针状球体（棘细胞1）的形状变化可由细胞内Ca 2+浓度增加引起（参考文献2 - 5）。我们已经发现，提高细胞内[Ca 2 +]的直接生化效应是增加1，2-二酰基甘油的产生并导致其在质膜中的积累。这种膜组成的变化可能会改变膜的结构，从而导致形状的变化。即使在不存在Ca 2+的情况下，能量耗尽的细胞也显示出1，2-二酰基甘油的增加以及类似但不太极端的形态变化。
THE change in shape of erythrocytes from the normal biconcave disk to a spiculed sphere (echinocyte1) can be caused by an increased intracellular concentration of Ca2+(refs 2 to 5). We have found that an immediate biochemical effect of raising intracellular [Ca2+] is to increase the production of 1,2-diacylglycerol and cause its accumulation in the plasma membrane. This change in membrane composition may alter the structure of the membrane and thus cause the change in shape. Energy-depleted cells also show increased 1,2-diacylglycerol and similar but less extreme morphological changes, even in the absence of Ca2+.