The epitranscriptome and synaptic plasticity
The epitranscriptome and synaptic plasticity
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DOI：
10.1016/j.conb.2019.04.007
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发表时间：
2019-12-01
影响因子：
5.7
通讯作者：
Meyer, Kate D.
中科院分区：
文献类型：
--
作者：
Flamand, Mathieu N.;Meyer, Kate D.
RNA修饰，统称为“表转录组”，最近已经成为细胞mRNA的普遍特征，对基因表达具有不同的影响。在过去的几年里，技术进步提高了我们识别mRNA修饰的能力，加上发现了添加和去除这些标记的蛋白质，大大扩展了我们对表位转录组如何塑造基因表达的知识。努力揭示mRNA修饰的功能作用已经开始揭示神经系统内的一些标记的重要作用，并且已经出现了动物模型，其显示了由mRNA修饰机制的丧失引起的严重神经发育和神经认知异常。在这里，我们回顾了最近的进展，在该领域的neuroepitranscriptomics，特别强调在大脑内的mRNA的修饰有助于突触活动。
RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these marks, have substantially expanded our knowledge of how the epitranscriptome shapes gene expression. Efforts to uncover functional roles for mRNA modifications have begun to reveal important roles for some marks within the nervous system, and animal models have emerged which demonstrate severe neurodevelopmental and neurocognitive abnormalities resulting from the loss of mRNA modification machinery. Here, we review the recent advances in the field of neuroepitranscriptomics, with a particular emphasis on how modifications to mRNAs within the brain contribute to synaptic activity.