Pediatric acute lymphoblastic leukemia and exposure to pesticides.
Pediatric acute lymphoblastic leukemia and exposure to pesticides.
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DOI：
10.1097/ftd.0b013e3181aae982
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发表时间：
2009-08
影响因子：
2.5
通讯作者：
Nelson D
中科院分区：
文献类型：
--
作者：
Soldin OP;Nsouli-Maktabi H;Genkinger JM;Loffredo CA;Ortega-Garcia JA;Colantino D;Barr DB;Luban NL;Shad AT;Nelson D
有机磷酸盐是环境中无处不在的农药，并被认为是急性淋巴细胞白血病的危险因素之一（所有）病例对照研究是对所有被诊断出患有所有人的儿童及其母亲（n = 41个子女对）的研究2005年1月至2008年1月之间，华盛顿特区的中心和儿童医疗中心。年龄，性别和居住县的案件和对照匹配。 - 高分辨率的质谱法。在房屋中（p <0.02）。有机磷酸盐代谢物的对照（p <0.03）和二硫代磷酸盐（P <0.05）。农药暴露值得进一步研究以确认该关联。
Organophosphates are pesticides ubiquitous in the environment and have been hypothesized as one of the risk factors for acute lymphoblastic leukemia (ALL). In this study, we evaluated the associations of pesticide exposure in a residential environment with the risk for pediatric ALL. This is a case–control study of children newly diagnosed with ALL, and their mothers (n = 41 child–mother pairs) were recruited from Georgetown University Medical Center and Children's National Medical Center in Washington, DC, between January 2005 and January 2008. Cases and controls were matched for age, sex, and county of residence. Environmental exposures were determined by questionnaire and by urinalysis of pesticide metabolites using isotope dilution gas chromatography–high-resolution mass spectrometry. We found that more case mothers (33%) than controls (14%) reported using insecticides in the home (P < 0.02). Other environmental exposures to toxic substances were not significantly associated with the risk of ALL. Pesticide levels were higher in cases than in controls (P < 0.05). Statistically significant differences were found between children with ALL and controls for the organophosphate metabolites diethylthiophosphate (P < 0.03) and diethyldithiophosphate (P < 0.05). The association of ALL risk with pesticide exposure merits further studies to confirm the association.