In vitro and in vivo characterization of novel plasma treated nickel titanium shape memory alloy for orthopedic implantation
In vitro and in vivo characterization of novel plasma treated nickel titanium shape memory alloy for orthopedic implantation
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DOI：
10.1016/j.surfcoat.2007.07.093
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发表时间：
2007-12
影响因子：
5.4
通讯作者：
K. Yeung;R. Chan;K. Lam;Shuilin Wu;Xiangmei Liu;C. Chung;P. Chu;W. Lu;D. Chan;K. Luk;K. Cheung
中科院分区：
文献类型：
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作者：
K. Yeung;R. Chan;K. Lam;Shuilin Wu;Xiangmei Liu;C. Chung;P. Chu;W. Lu;D. Chan;K. Luk;K. Cheung
镍钛（NiTi）形状记忆合金具有超弹性和形状记忆效应，这是目前其他医用金属材料所不具备的，因此在骨科和牙科植入中具有非常重要的潜力。然而，可能的镍离子释放阻碍了它们的医疗应用，特别是在骨科植入物中，关节表面总是会出现微动。我们利用等离子体浸没离子注入（PIII）来改变材料的表面化学性质，以减少镍的释放。增强的耐蚀性和表面机械性能已被报道过。本文描述了处理和未处理的PIII样品的细胞相容性和体内性能。采用40kv氮氧PIII处理镍含量为50.8%的NiTi盘。PIII后，表面形成氮化钛（TiN）和填充氧化钛（TiO）。未处理和氧处理样品的细胞增殖程度略低于氮处理样品。然而，在所有时间点，氮等离子体处理样品的体内骨形成比未处理的对照和氧处理的样品更好。因此，我们的工作提供了证据，证明氮等离子体修饰的NiTi合金可能适用于骨科，而不会产生有害的生物效应。
Nickel–titanium (NiTi) shape memory alloys are potentially very useful in orthopedic and dental implantation, since the materials possess super-elasticity and shape memory effects that other current medical metallic materials do not have. Possible nickel ion release, however, hampers their medical applications, particularly in orthopedic implants where fretting is always expected at the articulating surface. We have utilized plasma immersion ion implantation (PIII) to alter the surface chemistry of the materials in order to reduce nickel release. The enhanced corrosion resistance and surface mechanical properties have been reported previously. This paper describes the cytocompatibility and in vivo performance of the PIII treated and untreated samples. NiTi discs with 50.8% Ni were treated by nitrogen and oxygen PIII at 40 kV. After PIII, titanium nitride (TiN) and packed titanium oxide (TiO) are formed on the surface. The degree of cell proliferation on the untreated and oxygen treated samples is slightly inferior to that on the nitrogen treated sample. However, in vivo bone formation on the nitrogen plasma treated samples is better compared to the untreated control and oxygen treated one at all time points. Our work thus provides the evidence that nitrogen plasma modified NiTi alloys are potentially suitable for orthopedics without inducing harmful biological effects.