A genetic basis for the inviability of hybrids between sibling species of Drosophila.
A genetic basis for the inviability of hybrids between sibling species of Drosophila.
复制标题
果蝇同胞物种之间杂交无法生存的遗传基础。
DOI：
10.1093/genetics/124.4.909
复制
发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
Michael Ashburner
中科院分区：
文献类型：
--
作者：
Pierre Hutter;John Rootet;Michael Ashburner
黑腹果蝇的一种突变，其唯一已知的作用是挽救原本致命的种间杂交。该突变Hmr定位于1-31.84(9d1-9E4)。HMR可能是P元件插入的结果。它从雌性黑腹盘猴与其三个兄弟物种--模拟盘尾盘藻、毛盘盘尾轮虫和塞氏盘尾轮虫的雄性杂交中解救出杂交雄性。这种拯救是隐性的，因为同时携带Hmr和预期Hmr+的复制的杂交雄性不会被拯救。HMR还拯救了原本无法存活的雌性杂交种，从化合物-X-D黑腹果蝇雌性与其兄弟物种雄性的杂交中解救出来。这种救助也是隐性的，因为Hmr的复合-X杂合子不会救助。另一种突变，发现在黑腹金龟的in(1)AB染色体上，也被发现挽救了通常无法存活的物种杂交：然而，与Hmr不同的是，in(1)AB从in(1)AB/Y雄性到兄弟姐妹雌性的杂交中拯救了杂交雌性，以及从in(1)AB雌性和兄弟姐妹雄性的杂交中拯救了杂交雄性。这些数据是基于互补基因杂交无效的遗传基础的模型来解释的。
A mutation of Drosophila melanogaster whose only known effect is the rescue of otherwise lethal interspecific hybrids has been characterized. This mutation, Hmr, maps to 1-31.84 (9D1-9E4). Hmr may be the consequence of a P element insertion. It rescues hybrid males from the cross of D. melanogaster females to males of its three sibling species, D. simulans, D. mauritiana and D. sechellia. This rescue is recessive, since hybrid males that carry both Hmr and a duplication expected to be Hmr+ are not rescued. Hmr also rescues the otherwise inviable female hybrids from the cross of compound-X D. melanogaster females to males of its sibling species. This rescue is also recessive, since a compound-X heterozygous for Hmr does not rescue. Another mutation, discovered on the In(1)AB chromosome of D. melanogaster, is also found to rescue normally inviable species hybrids: unlike Hmr, however, In(1)AB rescues hybrid females from the cross of In(1)AB/Y males to sibling females, as well as hybrid males from the cross of In(1)AB females to sibling males. These data are interpreted on the basis of a model for the genetic basis of hybrid inviability of complementary genes.