Total Synthesis of Amphidinolide Q
Total Synthesis of Amphidinolide Q
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DOI：
10.1021/ol902026f
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发表时间：
2009-11-05
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, Jun'ichi
中科院分区：
文献类型：
--
作者：
Hangyou, Masahiro;Ishiyama, Haruaki;Kobayashi, Jun'ichi
Amphidinide Q 是一种来自培养的甲藻 Amphidinium sp. 的细胞毒性大环内酯，通过 Julia 偶联、Myers 烷基化和 Yamaguchi 内酯化完成了不对称合成。通过比较合成和天然两栖类内酯Q的NMR数据和α(D)值，证实两栖类内酯0的绝对构型为1。
Asymmetric synthesis of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished with Julia coupling, Myers alkylation, and Yamaguchi lactonization. The absolute configuration of amphidinolide 0 was confirmed to be 1 from comparison of the NMR data and [alpha](D) values of synthetic and natural amphidinolide Q.