Ultrasonic measurement of vascular scaffold elasticity using catheter system
Ultrasonic measurement of vascular scaffold elasticity using catheter system
复制标题
使用导管系统超声测量血管支架弹性
DOI：
10.1109/iembs.2008.4650410
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Shiina
中科院分区：
文献类型：
--
作者：
N. Nitta;T. Yamane;Goki Matsumura;T. Shiina
移植血管支架的表征是评价其生物相容性、成熟度和结构强度的关键。血管支架的力学性能与支架的生物相容性、成熟度和结构强度密切相关，因此定量测量血管支架的弹性模量值为支架的表征提供了有力的帮助。在先前的研究中，我们已经提出了一种组织工程血管移植前后的体外或体内测量系统，在本研究中，我们提出了一种新的、改进的方法来对血管支架进行体内评估和随访。测量的定量弹性模数被转换为用于活体评估的再生分数。利用犬的体内实验数据验证了所提出的评价方法的有效性。
Characterization of grafted vascular scaffold is essential for evaluating its biocompatibility, maturity and structural intensity. Quantitative elastic modulus measurement of vascular scaffold powerfully assists its characterization because the mechanical property is closely related with the biocompatibility, maturity and structural intensity of the vascular scaffold. We have presented an in vitro or in vivo measurement system for the tissue-engineered vessel before and after grafting in the previous study, we present a novel and modified method for in vivo assessment and follow-up of the vascular scaffold in this study. The measured quantitative elastic modulus is converted into the regeneration score for in vivo assessment. The effectiveness of the proposed evaluation method was validated by in vivo experimental data using canines.