Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.
Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.
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发表时间：
2010-03
影响因子：
1.5
通讯作者：
P. Pantazis;A. Varman;C. Simpson‐Durand;J. Thorpe;S. Ramalingam;D. Subramaniam;C. Houchen;M. Ihnat;S. Anant;Rama P. Ramanujam
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作者：
P. Pantazis;A. Varman;C. Simpson‐Durand;J. Thorpe;S. Ramalingam;D. Subramaniam;C. Houchen;M. Ihnat;S. Anant;Rama P. Ramanujam
三价砷[As(III)]目前被FDA批准用于治疗慢性和急性白血病。然而，As(III)也显示出对人类健康的破坏性影响，包括心血管疾病、糖尿病和癌症的发展。此外，As(III)是一种有效的血管生成剂。在此背景下，姜黄素，饮食制剂姜黄素的活性成分，显示出强大的抗增殖、抗炎和抗血管生成特性。在这份报告中，我们发现姜黄素和姜黄素都能抑制暴露于As(III)的HCT-116人结肠癌细胞中血管内皮生长因子的表达。此外，在鸡绒毛膜尿囊膜分析模型中，低浓度的As(III)处理会导致血管密度的广泛增加，然而，在姜黄素或姜黄素的存在下，血管密度会减少。总之，这里报道的结果强烈表明，姜黄和姜黄素可以显著减弱低浓度As(III)诱导的血管生成过程。
Trivalent arsenic [As(III)] is currently approved by the FDA for the treatment of chronic and acute leukemias. However, As(III) has also demonstrated damaging effects on human health, including development of cardiovascular disease, diabetes, and cancer. Further, As(III) is a potent angiogenic agent. In this context, curcumin, an active ingredient in the dietary agent turmeric, has demonstrated potent antiproliferative, antiinflammatory, and antiangiogenic properties. In this report, we have shown that both curcumin and turmeric inhibit expression of vascular endothelial growth factor in HCT-116 human colon cancer cells exposed to As(III). Further, in the chicken chorioallantoic membrane assay model, treatment with low As(III) concentrations results in extensive increase in blood vessel density, which, however, is reduced in the presence of curcumin or turmeric. Collectively, the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations.