THYROTOXICOSIS AND A THYROTROPIN-SECRETING PITUITARY-TUMOR CAUSING UNILATERAL EXOPHTHALMOS
THYROTOXICOSIS AND A THYROTROPIN-SECRETING PITUITARY-TUMOR CAUSING UNILATERAL EXOPHTHALMOS
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DOI：
10.1210/jcem-53-2-338
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发表时间：
1981-01-01
影响因子：
5.8
通讯作者：
CAPEN, CC
中科院分区：
文献类型：
--
作者：
YOVOS, JG;FALKO, JM;CAPEN, CC
Hyperthyroidism due to a TSH-secreting pituitary tumor has been noted by a number of investigators. A unique case is described in which a 17-yr-old female presented with clinical hyperthyroidism, a goiter, and unilateral exophthalmos. Serum T4 [thyroxine], free T4, and T3 [triiodothyronine] (radioimmunoassay) were consistently elevated along with elevated TSH levels (range, 10-100 .mu.U/ml). Skull X-rays and computed tomography scan revealed a tumor invading the right orbit. Other pituitary function studies were normal and LATS [long acting thyroid stimulator] was undetectable. Surgery performed resulted in 70% removal of the pituitary tumor and confirmed the presence of tumor infiltration into the right orbit. TRH tests done pre- and postoperatively (patient still clinically hyperthyroid with elevated T4 and TSH levels) showed TSH and prolactin responsiveness. EM of the tumor demonstrated features typical of pituitary thyrotrophs. Monolayer cultures of pituitary cells released TSH over time into the media but did not respond to TRH stimulation. Pituitary adenoma tissue content of immunoreactive TSH was 65 .mu.U/g wet tissue and demonstrated immunosimilarity with human standard. The patient had a TSH-secreting pituitary tumor responsive to TRH stimulation.
