Blood pressure, pulse, and neurohumoral responses to nitroprusside-induced hypotension in normotensive aging men.
Blood pressure, pulse, and neurohumoral responses to nitroprusside-induced hypotension in normotensive aging men.
复制标题
血压正常的老年男性对硝普钠引起的低血压的血压、脉搏和神经体液反应。
DOI：
10.1093/geronj/46.4.m151
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Rowe,JW
中科院分区：
文献类型：
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作者：
Minaker,KL;Meneilly,GS;YounG,JB;Landsberg,L;Stoff,JS;Robertson,GL;Rowe,JW
为了评估年龄对血压、脉搏和对低血压应激的神经体液反应的影响，我们给健康的年轻人和老年人注射硝普钠，直到平均动脉血压比基础血压降低 20%。老年受试者对硝普钠更敏感。老年人对这种低血压应激的脉搏增加明显减少，但肾素、加压素和去甲肾上腺素的反应在年轻人和老年人之间没有差异。我们得出的结论是，心脏加速是对抗低血压的主要防御措施之一，它会随着年龄的增长而受到损害。然而，老年人对低血压的神经体液反应是完整的。
In order to assess the effects of age on blood pressure, pulse, and neurohumoral responses to hypotensive stress, we infused nitroprusside into healthy young and old men until mean arterial blood pressure was reduced 20% from basal. Elderly subjects were much more sensitive to nitroprusside. Pulse increases in response to this hypotensive stress were markedly reduced in the elderly, but renin, vasopressin, and norepinephrine responses were not different between young and old. We conclude that cardioacceleration, one of the primary defenses against hypotension, is impaired with age. However, neurohumoral responses to hypotension are intact in the elderly.