Asymmetric hydroamination/cyclization catalyzed by group 4 metal complexes with chiral biaryl-based ligands
Asymmetric hydroamination/cyclization catalyzed by group 4 metal complexes with chiral biaryl-based ligands
复制标题
具有手性联芳基配体的第 4 族金属配合物催化的不对称氢胺化/环化
DOI：
10.1016/j.jorganchem.2010.07.034
复制
发表时间：
2011-01-01
影响因子：
2.3
通讯作者：
Zi, Guofu
中科院分区：
文献类型：
--
作者：
Zi, Guofu
基于手性联芳基配体的第4族金属配合物通过方便的胺消除步骤容易地制备，并且它们是氨基烯烃的不对称氢胺化/环化的有效催化剂。基于联芳基的配体是高度模块化的，使得能够容易地调节催化剂反应性和选择性。使用空间位阻的C-2-对称的钛和锆的间异丙基酰胺配合物如[1，1 '-（C10 H10）（2）-2，2'-{NCO（2，4，6-Me 3C 6 H2）}（2）]M（NMe 2）（2）（M = Ti，Zr），以优异的对映体过量（高达93%）获得了相应的杂环产物。这些结果在这篇简短的评论中介绍。(C)2010 Elsevier B. V.保留所有权利。
Group 4 metal complexes based on chiral biaryl ligands are readily prepared by a convenient amine elimination procedure, and they are efficient catalysts for the asymmetric hydroamination/cyclization of aminoalkenes. The biaryl-based ligands are highly modular enabling facile tuning of the catalyst reactivity and selectivity. The corresponding heterocyclic products have been obtained in excellent enantiomeric excesses (up to 93%) using sterically hindered C-2-symmetric titanium and zirconium mesitoylamidate complexes such as [1,1'-(C10H10)(2)-2,2'-{NCO(2,4,6-Me3C6H2)}(2)]M(NMe2)(2) (M = Ti, Zr). These results are presented in this short review. (C) 2010 Elsevier B.V. All rights reserved.