Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development.
Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development.
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母亲补充铁可以减轻围产期铜缺乏的影响，但不能消除低三碘甲状腺氨酸血症或感觉运动发育受损。
DOI：
10.1016/j.jnutbio.2010.09.007
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Prohaska,JosephR
中科院分区：
文献类型：
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作者：
Bastian,ThomasW;Lassi,KatieC;Anderson,GrantW;Prohaska,JosephR
铜、铁和碘/甲状腺激素（TH）缺乏会破坏大脑发育。新生儿铜缺乏导致铁缺乏，并可能影响甲状腺状态。这些研究的目的之一是确定通过在饮食中补充铁来改善缺铜后铁状态的影响。在怀孕的Holtzman[实验1（实验1）]或Sprague-Dawley[实验2（实验2）]大鼠中，使用两种不同的饮食会产生铜缺乏症。试验2中，饲粮铁含量由35 mg/kg提高至75 mg/kg。两种实验中，出生第24天（P24）铜缺乏（CuD）大鼠的血红蛋白、血清铁和血清三碘甲状腺原氨酸（T3）浓度均降低。然而，实验1中CuD P24大鼠的脑铁较低。实验2中CuA充足P24大鼠的血红蛋白和血清铁均高于实验1。实验2中Cu和th缺乏的大鼠在3个月的补充后表现出类似的感觉运动功能缺陷。结果表明，缺铜可能影响TH状态，而不影响其对铁生物学的影响。需要进一步的研究来阐明Cu， Fe和TH在大脑发育中的个体作用。
Copper, iron and iodine/thyroid hormone (TH) deficiencies disrupt brain development. Neonatal Cu deficiency causes Fe deficiency and may impact thyroidal status. One purpose of these studies was to determine the impact of improved iron status following Cu deficiency by supplementing the diet with iron. Cu deficiency was produced in pregnant Holtzman [Experiment 1 (Exp. 1)] or Sprague-Dawley [Experiment 2 (Exp. 2)] rats using two different diets. In Exp. 2, dietary Fe content was increased from 35 to 75 mg/kg according to NRC guidelines for reproduction. Cu-deficient (CuD) Postnatal Day 24 (P24) rats from both experiments demonstrated lower hemoglobin, serum Fe and serum triiodothyronine (T3) concentrations. However, brain Fe was lower only in CuD P24 rats in Exp. 1. Hemoglobin and serum Fe were higher in Cu adequate (CuA) P24 rats from Exp. 2 compared to Exp. 1. Cu- and TH-deficient rats from Exp. 2 exhibited a similar sensorimotor functional deficit following 3 months of repletion. Results suggest that Cu deficiency may impact TH status independent of its impact on iron biology. Further research is needed to clarify the individual roles for Cu, Fe and TH in brain development.