Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection
Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection
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DOI：
10.1073/pnas.95.15.8869
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Fauci, AS
中科院分区：
文献类型：
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作者：
Chun, TW;Engel, D;Fauci, AS
在接受抗逆转录病毒治疗(HAART)的慢性感染者和接受高效抗逆转录病毒治疗(HAART)的患者中，已经证明存在携带有复制能力的HIV-I的潜伏感染的静止CD4(+)T细胞，然而，尚不清楚是否可以通过在初次感染后早期启动HAART来阻止潜伏感染CD4(+)T细胞池的建立。本研究表明，尽管在实施HAART后不久血浆病毒血症得到了成功的控制，但在HIV-1感染的症状出现后10天就开始对感染者进行HAART并不能阻止携带整合的HIV-1 DNA的潜伏感染的静息CD4(+)T细胞的产生和传染性HIV-I的产生。此外，在研究期间的HAART持续时间(范围：0.2-17个月)或在初次HIV-1感染症状出现后开始HAART的时间(范围：0.3-4个月)与携带整合的HIV-1 DNA或感染病毒的静止CD4(+)T细胞的频率之间没有相关性。这些结果强调了在原发HIV-1感染中建立潜伏库的速度，并表明，只要在血浆病毒血症明显后开始治疗，在原发感染期间的早期治疗不太可能阻止潜伏感染的静止CD4(+)T细胞池的建立。
The presence of latently infected, resting CD4(+) T cells carrying replication-competent HIV-I has been demonstrated in chronically infected individuals who are antiretroviral therapy naive as well as in those who are receiving highly active antiretroviral therapy (HAART), It is not clear, however, whether the establishment of a pool of latently infected CD4(+) T cells can be blocked by early initiation of HAART after primary infection. The present st;dy demonstrates that initiation of HAART in infected individuals as early as 10 days after the onset of symptoms of primary HIV-1 infection did not prevent generation of latently infected, resting CD4(+) T cells carrying integrated HIV-1 DNA as well as infectious HIV-I despite the successful control of plasma viremia shortly after institution of HAART. Furthermore, there was no correlation between either the duration of HAART at the time of study (range: 0.2-17 months) or the time of initiation of HAART after the onset of symptoms of primary HIV-1 infection (range: 0.3-4 months) and the frequencies of resting CD4(+) T cells carrying either integrated HIV-1 DNA or infectious virus. These results underscore the rapidity with which latent reservoirs are established in primary HIV-1 infection and indicate that it is unlikely that early treatment during primary infection can prevent establishment of a pool of latently infected, resting CD4(+) T cells as long as treatment is initiated after plasma viremia becomes evident.