Activation machinery of the small GTPase Arf6
Activation machinery of the small GTPase Arf6
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DOI：
10.1016/j.jbior.2013.09.014
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Kanaho, Yasunori
中科院分区：
文献类型：
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作者：
Hongu, Tsunaki;Kanaho, Yasunori
小G蛋白ADP-核糖基化因子6（Arf 6）在各种类型的细胞中的多种细胞事件中起关键作用，包括胞吐、胞吞、肌动蛋白细胞骨架重组和磷酸肌醇代谢。为了控制Arf 6的如此广泛的各种各样的作用，Arf 6的激活可以通过其激活剂鸟嘌呤核苷酸交换因子（GEF）在空间和时间上精确地控制。在这篇手稿中，我们总结和讨论的特点，以前确定的GEFs的Arf 6和激活机制的Arf 6。(C)2013爱思唯尔有限公司保留所有权利。
The small GTPase ADP-ribosylation factor 6 (Arf6) plays pivotal roles in a wide variety of cellular events, including exocytosis, endocytosis, actin cytoskeleton reorganization and phosphoinositide metabolism, in various types of cells. To control such a wide variety of actions of Arf6, activation of Arf6 could be precisely controlled by its activators, guanine nucleotide exchange factors (GEFs), in spatial and temporal manners. In this manuscript, we summarize and discuss the characteristics of previously identified GEFs specific to Arf6 and activation machineries of Arf6. (C) 2013 Elsevier Ltd. All rights reserved.