EFFECT OF TRANSDERMAL NICOTINE PATCHES ON CIGARETTE-SMOKING - A DOUBLE-BLIND CROSSOVER STUDY
EFFECT OF TRANSDERMAL NICOTINE PATCHES ON CIGARETTE-SMOKING - A DOUBLE-BLIND CROSSOVER STUDY
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DOI：
10.1007/bf02245429
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发表时间：
1992-03-01
影响因子：
3.4
通讯作者：
RUSSELL, MAH
中科院分区：
文献类型：
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作者：
FOULDS, J;STAPLETON, J;RUSSELL, MAH
在30例受试者中，通过在不使用贴剂的情况下吸烟一周期间测量吸烟的行为、生化和主观方面，然后在随机双盲交叉设计中使用尼古丁和安慰剂贴剂各一周，检查尼古丁透皮贴剂对随意吸烟的影响。当佩戴尼古丁贴片时，受试者并没有减少吸烟的数量，但他们呼出的一氧化碳减少了14%，他们从吸烟中获得的满意度降低了，并且报告了更少和更弱的吸烟欲望。从香烟中摄入尼古丁的下调是不精确的，因此当受试者佩戴尼古丁贴片时，其吸烟后血浆尼古丁浓度平均增加至45 ng/ml，而在无贴片和安慰剂贴片条件下均为37 ng/ml。由于尼古丁贴片在禁欲受试者中产生的血浆尼古丁浓度为15.9 ng/ml，这表明佩戴尼古丁贴片时从香烟中摄入的尼古丁减少了22%。未报告尼古丁过量的严重症状。有人建议，尼古丁从贴片的连续吸收可能会导致急性耐受性的建立，从吸烟的毒性和愉快的主观影响。
The effect of transdermal nicotine patches on ad libitum cigarette smoking was examined in 30 subjects by measuring behavioural, biochemical and subjective aspects of smoking during a week of smoking without patches, and then a week each of nicotine and placebo patches in a randomised double blind crossover design. While wearing nicotine patches the subjects did not reduce the number of cigarettes smoked, but their expired carbon monoxide was reduced by 14%, they obtained less satisfaction from their cigarettes, and reported fewer and weaker urges to smoke. Down-regulation of nicotine intake from cigarettes was imprecise, such that when subjects wore nicotine patches their post-cigarette plasma nicotine concentration increased to an average of 45 ng/ml compared with 37 ng/ml in both no patch and placebo patch conditions. As the nicotine patches produced a plasma nicotine concentration of 15.9 ng/ml in abstinent subjects, this suggests a 22% reduction in nicotine intake from cigarettes while wearing nicotine patches. No serious symptoms of nicotine overdose were reported. It is suggested that the continuous absorption of nicotine from the patch may cause a build-up of acute tolerance to both toxic and pleasant subjective effects from-smoking.