Growth of a highly virulent strain of Mycobacterium tuberculosis in mice of differing susceptibility to tuberculous challenge
Growth of a highly virulent strain of Mycobacterium tuberculosis in mice of differing susceptibility to tuberculous challenge
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DOI：
10.1054/tuld.1999.0214
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Collins, F. M.
中科院分区：
文献类型：
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作者：
Kelley, C. L.;Collins, F. M.
在最近农村社区爆发的结核病疫情中，结核分枝杆菌菌株 CDC 1551 表现出异常高水平的感染性和毒力。静脉内或气源性感染结核分枝杆菌 CDC 1551 的小鼠在肺和脾中出现感染，这与结核分枝杆菌菌株 Erdman、H37Rv 和 Indian 的感染几乎相同。静脉注射 CDC 1551、Erdman 或 H37Rv 的小鼠在 3 个月内的存活率也没有显着差异。旨在检测 3 种近交系小鼠中 CDC 1551 和 Erdman 生长速率差异的研究未能解释 CDC 1551 在暴露于这种生物体的人群中表现出的高水平传染性和毒力。
Mycobacterium tuberculosis strain CDC 1551 exhibited unusually high levels of infectivity and virulence during a recent outbreak of tuberculosis in a rural community. Mice infected intravenously or aerogenically with M. tuberculosis CDC 1551 developed infections in the lungs and spleen which were almost identical with those for M. tuberculosis strains Erdman, H37Rv and Indian. There was also no significant difference in the survival rates of mice infected intravenously with CDC 1551, Erdman or H37Rv over a 3-month period. Studies designed to detect differences in the growth rates of CDC 1551 and Erdman in 3 inbred strains of mice failed to explain the high level of infectiousness and virulence expressed by CDC 1551 in human populations exposed to this organism.