Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia.
Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia.
复制标题
慢性创伤性脑病：与阿尔茨海默病和额颞叶痴呆的比较。
DOI：
10.1055/s-0040-1715134
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发表时间：
2020
影响因子：
2.7
通讯作者：
Rabinovici,GilD
中科院分区：
文献类型：
--
作者：
Lesman-Segev,OritH;Edwards,Lauren;Rabinovici,GilD
慢性创伤性脑病（CTE）的临床诊断是具有挑战性的，由于异质性的临床表现和重叠与其他神经退行性痴呆。根据临床表现，CTE的鉴别诊断包括阿尔茨海默病（AD）、行为变异性额颞叶痴呆（bvFTD）、帕金森病、肌萎缩侧索硬化症、原发性情绪障碍、创伤后应激障碍和精神病性障碍。本文旨在比较CTE与AD和bvFTD的临床方面、遗传学、液体生物标志物、影像学、治疗和病理学。详细的临床评估，神经认知评估和结构脑成像可以告知鉴别诊断，而分子生物标志物可以帮助排除潜在的AD病理。前瞻性研究，包括临床病理学的相关性，需要建立工具，可以更准确地确定在CTE的风险患者的神经精神下降的原因。
The clinical diagnosis of chronic traumatic encephalopathy (CTE) is challenging due to heterogeneous clinical presentations and overlap with other neurodegenerative dementias. Depending on the clinical presentation, the differential diagnosis of CTE includes Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease, amyotrophic lateral sclerosis, primary mood disorders, posttraumatic stress disorder, and psychotic disorders. The aim of this article is to compare the clinical aspects, genetics, fluid biomarkers, imaging, treatment, and pathology of CTE to those of AD and bvFTD. A detailed clinical evaluation, neurocognitive assessment, and structural brain imaging can inform the differential diagnosis, while molecular biomarkers can help exclude underlying AD pathology. Prospective studies that include clinicopathological correlations are needed to establish tools that can more accurately determine the cause of neuropsychiatric decline in patients at risk for CTE.