Subsets of activated T cells in patients with systemic lupus erythematosus: the relation to cell cycle.
Subsets of activated T cells in patients with systemic lupus erythematosus: the relation to cell cycle.
复制标题
系统性红斑狼疮患者的活化 T 细胞亚群：与细胞周期的关系。
DOI：
--
复制
发表时间：
1997
影响因子：
2.1
通讯作者：
S. Hirose
中科院分区：
文献类型：
--
作者：
Y. Tokano;S. Morimoto;T. Hishikawa;A. Murashima;M. Abe;I. Sekigawa;Y. Takasaki;H. Hashimoto;K. Okumura;T. Shirai;S. Hirose
本文研究了系统性红斑狼疮（SLE）患者活化T细胞的各种标志物（可溶性白细胞介素2受体（sIL-2 R）、HLA-DR+和HLA-DP+ T细胞、增殖细胞核抗原（PCNA）阳性淋巴细胞）之间的相关性，并与细胞周期有关。与正常对照组相比，sIL-2 R浓度及HLA-DR+ T细胞、HLA-DP+ T细胞和PCNA+淋巴细胞比例均显著升高。sIL-2 R水平与PCNA阳性淋巴细胞比例相关，而与HLA-DR阳性T细胞、HLA-DP阳性T细胞比例无关。sIL-2 R和PCNA+淋巴细胞之间的相关性归因于这两个指标在植物血凝素（PHA）刺激后的正常T细胞的G1 B或S期增加。在细胞周期分析后，发现活化的T细胞可以在G1 A和S期被发现。
The correlation among the various markers of activated T cells (soluble interleukin 2 receptor (sIL-2R), HLA-DR+ and HLA-DP+ T cells, proliferating cell nuclear antigen (PCNA) positive lymphocytes) were examined in patients with systemic lupus erythematosus (SLE), and related to the cell cycle. The concentration of sIL-2R and the proportion of HLA-DR+ T cells, HLA-DP+ T cells or PCNA+ lymphocytes were increased significantly as compared to that in normal subjects. And, the concentrations of sIL-2R correlated with the proportions of PCNA+ lymphocytes, but not with the proportions of HLA-DR+ T cells, HLA-DP+ T cells. The correlation between sIL-2R and PCNA+ lymphocytes was attributed to both indicators being increased during the G1B or S phase in normal T cells upon stimulation by phytohemagglutinin (PHA). Upon cell cycle analysis it was learned that activated T cells could be found in the G1A and the S phases.
影响因子：
4.4
作者：
M. Linker‐Israeli;R. Deans;D. Wallace;J. Prehn;T. Ozeri-Chen;J. Klinenberg
通讯作者：
M. Linker‐Israeli;R. Deans;D. Wallace;J. Prehn;T. Ozeri-Chen;J. Klinenberg
通过去除自发激活的抑制细胞来纠正系统性红斑狼疮患者白细胞介素 2 的产生。
DOI：
10.1172/jci111758
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Linker-Israeli,M;Bakke,AC;QuismorioJr,FP;Horwitz,DA
通讯作者：
Horwitz,DA
影响因子：
--
作者：
LIANG, MH;SOCHER, SA;SCHUR, PH
通讯作者：
SCHUR, PH