Elevated Bilirubin in Acute and Transient Psychotic Disorder
Elevated Bilirubin in Acute and Transient Psychotic Disorder
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DOI：
10.1055/s-0029-1237376
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Strik, W. K.
中科院分区：
文献类型：
--
作者：
Bach, D. R.;Kindler, J.;Strik, W. K.
导言：轻度未结合高胆红素血症在精神分裂症患者中似乎比其他精神病人或普通人群更常见，并与脑部改变有关。结果：我们发现急性和短暂性精神障碍(ATPD)与总胆红素水平和总胆红素升高的比率存在关联，与偏执型精神分裂症和分裂情感障碍患者相比，所有患者的总胆红素水平和总胆红素升高率均高于普通人群。结论：ATPD与精神分裂症/分裂情感障碍的差异可能与疾病的严重程度、病因学或环境因素有关。
Introduction: Mild unconjugated hyperbilirubinemia seems to be more common in patients with disorders from the schizophrenic spectrum than in other psychiatric patients or in the general population and has been linked to brain alterations. This spectrum however contains a number of diagnostic entities that might not share the same etiological and environmental factors.Methods: 325 hospital admissions were analysed over a one-year period.Results: We found an association of acute and transient psychotic disorders (ATPD) with total bilirubin level and rate of elevated total bilirubin that was increased compared to paranoid schizophrenia and schizoaffective disorder, all patients, and was higher than in the general population. Concomitant increased direct bilirubin might suggest that reduced UGT activity, causing Gilbert's syndrome in the general population, is not the reason for elevated bilirubin in ATPD.Conclusions: The difference between ATPD and schizophrenia/schizoaffective disorder might be due to disorder severity, aetiology, or environmental factors that influence enzyme activity.