The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing
The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing
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DOI：
10.1111/bdi.12068
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发表时间：
2013-06-01
影响因子：
5.4
通讯作者：
Nees, Frauke
中科院分区：
文献类型：
--
作者：
Heinrich, Angela;Lourdusamy, Anbarasu;Nees, Frauke
目标 双相情感障碍是一种严重的情绪障碍，通常始于青春期或成年早期，遗传率高达 80%。最大的双向情感障碍全基因组关联分析最近在 OZD4 (rs12576775) 中发现了一个新的全基因组关联变异。本研究的目的是利用成像遗传学方法进一步阐明这种风险变异在疾病过程中的作用。由于在奖赏和情绪处理过程中杏仁核和纹状体反应增加是双相情感障碍患者的特征，因此测试了风险变异是否对健康青少年的这种内表型有影响。方法 我们研究了风险变异 rs12576775 对青少年样本 (N=485) 功能磁共振成像数据的影响。在修改金钱激励延迟任务（检查奖励）和面部任务（检查情绪）期间，分析了杏仁核和纹状体中风险等位基因（G 等位基因）携带者和纯合 A 等位基因携带者之间的差异激活。结果 风险等位基因携带者在奖赏敏感性 (p=0.05) 和奖赏预期 (p
Objectives Bipolar disorder is a severe mood disorder, which normally begins during adolescence or early adulthood and has a heritability of up to 80%. The largest genome-wide association analysis of bipolar disorder recently identified a new genome-wide associated variant in OZD4 (rs12576775). The aim of the present study was to further elucidate the role of this risk variant in the disease process using an imaging genetics approach. As increased amygdala and striatal responses during the processing of reward and emotion are characteristic for bipolar disorder patients, it was tested whether the risk variant has an influence on this endophenotype in healthy adolescents. Methods We examined the impact of the risk variant rs12576775 on functional magnetic resonance imaging data in an adolescent sample (N=485). Differential activation between carriers of the risk allele (G-allele) and homozygous A-allele carriers in the amygdala and the striatum during a modification of the monetary incentive delay task (examining reward) and a face task (examining emotion) was analyzed. Results Carriers of the risk allele showed an increased blood oxygen level-dependent response in the amygdala during reward sensitivity (p=0.05) and reward expectation (p