FFY720 suppresses humoral immunity by inhibiting germinal center reaction
FFY720 suppresses humoral immunity by inhibiting germinal center reaction
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DOI：
10.1182/blood-2004-06-2075
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发表时间：
2004-12-15
期刊：
影响因子：
20.3
通讯作者：
Zheng, B
中科院分区：
文献类型：
--
作者：
Han, SH;Zhang, XJ;Zheng, B
FTY 720是一种新型的免疫抑制剂，在各种动物模型中对抑制同种异体移植物排斥反应和自身免疫非常有效。已经表明，鞘氨醇1磷酸（S1P）受体是FTY 720的直接分子靶标。然而，FTY 720抑制特异性免疫应答的机制尚未得到很好的解决。特别是，没有关于该化合物是否或如何影响体液免疫的可用信息。我们已经研究了FTY 720治疗在对明确定义的T依赖性抗原的免疫应答期间对B细胞应答的影响。我们的数据表明，在用FTY 720处理的小鼠的外周淋巴组织中，生发中心反应显著降低。此外，FTY720处理抑制高亲和力、类别转换抗体的产生，但不抑制低亲和力、免疫球蛋白M（IgM）抗体的产生。一致地，FTY 720对针对T非依赖性抗原的抗体应答没有显著影响。这些结果对FTY 720在免疫调节中的应用具有重要意义。(C)2004年，美国血液学会。
FTY720 is a novel immunosuppressant that is highly effective in inhibiting rejection of allografts and autoimmunity in various animal models. It has been shown that the sphingosine 1 phosphate (S1P) receptors are the direct molecular targets of FTY720. However, the mechanisms responsible for inhibiting specific immune responses by FTY720 are not well resolved. In particular, there is no available information on whether or how this compound affects humoral immunity. We have investigated the effect of FTY720 treatment on B-cell response during the immune response to a well-defined T-dependent antigen. Our data demonstrated that germinal center reaction was significantly reduced in peripheral lymphoid tissues of mice treated with FTY720. In addition, FTY720 treatment inhibited the production of high-affinity, class-switched antibodies, but not the production of low-affinity, immunoglobulin M (IgM) antibody. Consistently, FTY720 did not have a significant effect on antibody response to a T-independent antigen. Our results may have important implications in application of FTY720 in immune regulation. (C) 2004 by The American Society of Hematology.