Study on hemodynamics in patient-specific thoracic aortic aneurysm
Study on hemodynamics in patient-specific thoracic aortic aneurysm
复制标题
胸主动脉瘤患者血流动力学研究
DOI：
10.1063/2.1101401
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发表时间：
2011-01-01
影响因子：
3.4
通讯作者：
Liu, You-Jun
中科院分区：
文献类型：
--
作者：
Qiao, Ai-Ke;Fu, Wen-Yu;Liu, You-Jun
本研究的目的是研究特定患者胸主动脉瘤的血流动力学，并探讨主动脉斑块形成的原因。对具有梭形动脉瘤和3条主要分支血管的胸主动脉内的三维脉动血流进行了数值研究，平均雷诺数为1399，沃默斯利数为19.2。基于临床二维CT切片数据，利用医学图像处理软件构建了特定患者的几何模型。采用非定常、不可压缩的三维纳维 - 斯托克斯方程来求解流场。分析了心动周期内血流动力学变量的时间分布，如动脉和动脉瘤内的流线、壁面剪应力。基于特定患者模型和血流动力学模拟，可以分析该患者胸主动脉瘤的生长和破裂机制。（C）2011中国理论与应用力学学会。
The objective of this study is to investigate the hemodynamics in patient-specific thoracic aortic aneurysm and discuss the reason for formation of aortic plaque. A 3-Dimensional pulsatile blood flow in thoracic aorta with a fusiform aneurysm and 3 main branched vessels was studied numerically with the average Reynolds number of 1399 and the Womersley number of 19.2. Based on the clinical 2-Dimensional CT slice data, the patient-specific geometry model was constructed using medical image process software. Unsteady, incompressible, 3-Dimensional Navier-Stokes equations were employed to solve the flow field. The temporal distributions of hemodynamic variables during the cardiac cycle such as streamlines, wall shear stresses in the arteries and aneurysm were analyzed. Growth and rupture mechanisms of thoracic aortic aneurysm in the patient can be analyzed based on patient-specific model and hemodynamics simulation.