Inhibition of bacterial RNA polymerases. Peptide metabolites from the cultures of Streptomyces sp.
Inhibition of bacterial RNA polymerases. Peptide metabolites from the cultures of Streptomyces sp.
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DOI：
10.1021/np960709c
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发表时间：
1997-08-01
影响因子：
5.1
通讯作者：
Brasseur, MM
中科院分区：
文献类型：
--
作者：
Miao, SC;Anstee, MR;Brasseur, MM
用化学方法研究了一株链霉菌土壤菌株的发酵培养对大肠杆菌和金黄色葡萄球菌的RNA聚合酶的抑制活性。活性成分是最近从一种海洋链霉菌中发现的罕见的双环沉积肽盐酰胺A(1)。同样的提取物还产生了一个新的环六肽天然产物，desotamide(2)，其结构是基于氨基酸分析，详细的光谱数据解释和肽合成。
The fermentation culture of a soil strain of Streptomyces has been chemically investigated for its inhibitory activity against RNA polymerases from the bacteria Escherichia coli and Staphylococcus aureus. The active component was found to be the unusual bicyclodepsipeptide salinamide A (1) recently discovered from a marine Streptomycete. The same extract also yielded a new cyclohexapeptide natural product, desotamide (2), the structure elucidation of which was based on amino acid analysis, detailed spectroscopic data interpretation, and peptide synthesis.