Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis
Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis
复制标题
DOI：
10.1016/j.clineuro.2012.07.019
复制
发表时间：
2013-05-01
影响因子：
1.9
通讯作者：
Ando, Yukio
中科院分区：
文献类型：
--
作者：
Uchino, Makoto;Yamashita, Satoshi;Ando, Yukio
目的：多发性肌炎(PM)和皮肌炎(DM)的特征性病理肌肉表现反映其不同的发病机制。方法：对1970年至2009年间收治的215例PM和DM患者的肌肉活检结果进行分析。病变活检组织病理分为肌内浸润型、血管周围浸润型和少见浸润型3种类型。结果：恶性和非恶性PM患者的肌肉病理无明显差异。而DM伴恶性肿瘤组罕见浸润型肌肉病变的发生率显著高于无肿瘤组(P=0.0345)。(C)2012爱思唯尔B.V.保留所有权利。
Objective: The characteristic pathological muscular findings of polymyositis (PM) and dermatomyositis (DM) have been shown to reflect their different pathogeneses. Here, we characterized the muscle biopsy findings of PM and DM patients with or without malignancy.Methods: We evaluated the muscle biopsy findings of 215 consecutive PM and DM patients admitted to our hospital between 1970 and 2009. Pathology of the lesion biopsy sections was classified into 3 types: endomysial infiltration-type, perivascular infiltration-type, and rare-infiltrative-type.Results: There was no difference between the muscle pathology of PM patients with and without malignancy. However, the incidence of rare-infiltrative type muscle pathology in DM patients with malignancy was significantly higher than in those without such tumors (p = 0.0345).Conclusion: The incidence of rare-infiltrative type muscle pathology may be a predictive marker of DM with malignancy. (C) 2012 Elsevier B.V. All rights reserved.