Reduced-Dimension Modeling Approach for Simulating Recruitment/De-recruitment Dynamics in the Lung
Reduced-Dimension Modeling Approach for Simulating Recruitment/De-recruitment Dynamics in the Lung
复制标题
用于模拟肺部招募/解除招募动态的降维建模方法
DOI：
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发表时间：
2016
影响因子：
3.8
通讯作者：
D. Gaver
中科院分区：
文献类型：
--
作者：
Jason Ryans;H. Fujioka;D. Halpern;D. Gaver
急性呼吸窘迫综合征是一种需要使用机械通气的肺部疾病。然而，这可能会导致呼吸机诱导的肺损伤的发展，这是由肺泡组织的过度扩张和气道的反复关闭（再招募）和重新开放（再招募）引起的。在这项研究中，我们从降维方法开发了一个多尺度的肺模型，以研究气道塌陷和重开期间肺通气的动力学。该模型由一个不对称的几何网络组成，有16代液体内衬气道，气流由可变胸膜压力驱动。在呼吸周期中，气道半径和气道膜厚度的变化导致液体塞的形成，这些液体塞在整个气道网络中传播和破裂。模拟时，表面张力值为$$15 \le \gamma \le 25$$ 15≤γ≤25 dyn/cm。观察到，堵塞形成和破裂的开始时间取决于表面张力，以及堵塞在分叉处的聚集/分裂行为。此外，邻近气道（即母气道和子气道）中存在堵塞会显著影响堵塞的传播行为，从而影响分叉处的局部驱动压力分布，导致复杂的聚集和分裂行为。该模型提供了一种能够模拟正常和病理生理肺部状况的方法，具有用于个性化临床医学的潜力。
Acute respiratory distress syndrome is a pulmonary disease that requires the use of mechanical ventilation for patient recovery. However, this can lead to development of ventilator-induced lung injury caused by the over-distension of alveolar tissue and by the repetitive closure (de-recruitment) and reopening (recruitment) of airways. In this study, we developed a multi-scale model of the lung from a reduced-dimension approach to investigate the dynamics of ventilation in the lung during airway collapse and reopening. The model consisted of an asymmetric network geometry with 16 generations of liquid-lined airways with airflow driven by a variable pleural pressure. During the respiratory cycle changes in airway radii and film thickness yield the formation of liquid plugs that propagate and rupture throughout the airway network. Simulations were conducted with constant surface tension values $$15 \le \gamma \le 25$$15≤γ≤25 dyn/cm. It was observed that the time onset of plug creation and rupture depended on the surface tension, as well as the plug aggregation/splitting behavior at bifurcations. Additionally, the plug propagation behavior was significantly influenced by presence of plugs in adjacent airways (i.e. parent and daughters) that affected the driving pressure distribution locally at bifurcations and resulted in complex aggregation and splitting behavior. This model provides an approach that has the ability to simulate normal and pathophysiological lung conditions with the potential to be used in personalized clinical medicine.
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影响因子：
3.3
作者：
D. Otis;E. Ingenito;R. Kamm;Mark P. Johnson
通讯作者：
D. Otis;E. Ingenito;R. Kamm;Mark P. Johnson
影响因子：
3.3
作者：
GAVER, DP;SAMSEL, RW;SOLWAY, J
通讯作者：
SOLWAY, J
影响因子：
3.3
作者：
Albert, Scott P.;DiRocco, Joseph;Nieman, Gary F.
通讯作者：
Nieman, Gary F.
DOI：
10.1115/1.1798051
发表时间：
2004-10-01
影响因子：
1.7
作者：
Fujioka, H;Grotberg, JB
通讯作者：
Grotberg, JB