Dopamine transporter binding in depressed patients with anhedonia
Dopamine transporter binding in depressed patients with anhedonia
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DOI：
10.1016/j.pscychresns.2006.03.001
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发表时间：
2006-10-30
影响因子：
2.3
通讯作者：
De Risio, Sergio
中科院分区：
文献类型：
--
作者：
Sarchiapone, Marco;Carli, Vladimir;De Risio, Sergio
中枢多巴胺能功能障碍被广泛认为是快感缺乏精神病理表现的一种常见神经生物学相关性。多巴胺转运体(DAT)是一种主要的突触前受体，可能在多巴胺能传递的病理生理学中发挥关键作用。我们研究的目的是评估患有快感缺乏症的抑郁症患者中DAT的结合情况。应用放射性示踪剂DATcan单光子发射计算机断层扫描(SPECT)检测11例抑郁症快感缺乏症患者和9例健康对照的DAT结合情况。与健康受试者相比，患者的DAT结合率显著降低。在DAT结合率和接受心理测试的分数之间没有发现显著的相关性。这些发现提示快感缺乏抑郁患者的DAT密度改变，这可能是突触间隙多巴胺浓度降低的主要易感因素或次要现象。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Central dopaminergic dysfunction has been widely proposed as a common neurobiological correlate of the psychopathological expression of anhedonia. The dopamine transporter (DAT) is a predominantly presynaptic receptor that may play a critical role in the pathophysiology of dopaminergic transmission. The aim of our study was to evaluate DAT binding in a population of depressed patients with anhedonia. Single photon emission computed tomography (SPECT) with the radiotracer DATSCAN was used to evaluate DAT binding in 11 depressed patients with anhedonia and 9 healthy comparison subjects. Compared with healthy subjects, patients showed significantly lower DAT binding. No significant correlation was found between DAT binding ratios and scores on administered psychometric tests. These findings suggest an alteration in DAT density in depressed patients with anhedonia that may be a primary susceptibility factor or a secondary phenomenon to reduced dopamine concentration in the synaptic cleft. (c) 2006 Elsevier Ireland Ltd. All rights reserved.