Improvement of cell adhesion on poly(L-lactide) by atmospheric plasma treatment
Improvement of cell adhesion on poly(L-lactide) by atmospheric plasma treatment
复制标题
DOI：
10.1002/jbm.a.30521
复制
发表时间：
2006-04-01
影响因子：
4.9
通讯作者：
Takahashi, J
中科院分区：
文献类型：
--
作者：
Nakagawa, M;Teraoka, F;Takahashi, J
本研究的目的是阐明细胞与聚（L-丙交酯）（PLLA）样品表面之间的相互作用，这些样品在大气压下使用低温等离子体处理装置进行了改性。等离子体处理在空气、二氧化碳(CO 2 )和全氟丙烷(C 3 F 8 )气体的气氛中进行。通过XPS分析等离子体处理前后的PLLA样品及其与水的接触角。此外，使用MC3T3-E1细胞对PLLA样品进行细胞粘附能力和细胞团培养测试。结果表明，与未处理的样品相比，在空气或CO2气体中进行等离子体处理的样品的接触角有所减小。另一方面，与未处理的等离子体样品相比，在C3F8气体中进行等离子体处理的样品的接触角有所增加。在空气或 CO2 气体中等离子处理的 PLLA 样品的细胞响应明显优于在 C3F8 气体中等离子处理的 PLLA 样品。 (c) 2005 年 Wiley 期刊公司。
The purpose of this study is to elucidate the interaction between the cell and the surface of poly(L-lactide) (PLLA) samples, which were modified using a low-temperature plasma treatment apparatus at atmospheric pressure. The plasma treatments were carried out in the atmospheres of air, carbon dioxide (CO,), and perfluoro propane (C3F8) gas. The PLLA samples before and after the plasma treatment were analyzed by XPS and their contact angles with water. Furthermore, the cell adhesion capability and cell mass culturing tests on the PLLA samples were carried out using MC3T3-E1 cells. The results showed that the contact angle of the samples, which was plasma treated in air or in CO2 gas, decreased compared with that of the untreated samples. On the other hand, the contact angle of the samples, which was plasma treated in the C3F8 gas, increased compared with the untreated plasma samples. The cell response on the PLLA samples plasma treated in air or in the CO, gas were significantly superior to that of the PLLA samples, which was plasma treated in the C3F8 gas. (c) 2005 Wiley Periodicals, Inc.