Dysconnectivity in the frontoparietal attention network in schizophrenia.
Dysconnectivity in the frontoparietal attention network in schizophrenia.
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DOI：
10.3389/fpsyt.2013.00176
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发表时间：
2013
影响因子：
4.7
通讯作者：
Joyce EM
中科院分区：
文献类型：
--
作者：
Roiser JP;Wigton R;Kilner JM;Mendez MA;Hon N;Friston KJ;Joyce EM
认知障碍在精神分裂症患者中很常见，即使是那些相对保留功能的人在注意力任务上的表现也比健康志愿者（HVs）差。这与在注意力集中时激活的额顶叶网络（FPN）的连通性在精神分裂症中被破坏的假设是一致的。我们使用脑磁图（MEG）检查了精神分裂症患者FPN中注意力对连通性的影响。23名hv和19名首发精神分裂症患者在一项简单的视觉变化测试中进行了扫描，该测试已知可以激活FPN，在该测试中，通过正交闪烁检测任务监测和指导注意力。使用诱发反应的动态因果模型（DCM）来评估以下网络的有效连通性及其通过参与刺激维度变化的调制：高视觉区域；颞顶叶交界处；顶内沟；背前扣带皮层；腹外侧前额皮质。最终的MEG分析包括18名hiv患者和14名精神分裂症患者。虽然所有的参与者都能保持注意力，但hiv患者的反应比精神分裂症患者稍微准确，但并不明显。hiv患者，而非精神分裂症患者，对参与的视觉变化表现出更大的皮层反应。贝叶斯模型比较表明，同时存在自上而下和自下而上连接的注意依赖变化的DCM模型最能解释精神分裂症患者的反应，而在HVs中，最佳模型只需要自下而上的变化。连通性估计的定量比较揭示了右侧IPS-TPJ连接变化的显着组差异：精神分裂症患者在参与刺激变化期间表现出相对减少的连通性。至关重要的是，这种减少预示着较低的智力。这些数据与FPN功能连接障碍导致精神分裂症认知障碍的假设是一致的。
Cognitive impairment is common in patients with schizophrenia, and even those with relatively preserved function perform worse than healthy volunteers (HVs) on attentional tasks. This is consistent with the hypothesis that connectivity – in the frontoparietal network (FPN) activated during attention – is disrupted in schizophrenia. We examined attentional effects on connectivity in the FPN, in schizophrenia, using magnetoencephalography (MEG). Twenty-three HVs and 19 first-episode schizophrenia patients were scanned during a simple visual change test, known to activate the FPN, in which attention was monitored and directed with an orthogonal flicker-detection task. Dynamic causal modeling (DCM) of evoked responses was used to assess effective connectivity – and its modulation by changes in the attended stimulus dimension – in the following network: higher visual area; temporoparietal junction (TPJ); intraparietal sulcus (IPS); dorsal anterior cingulate cortex; and ventrolateral prefrontal cortex. The final MEG analysis included 18 HVs and 14 schizophrenia patients. While all participants were able to maintain attention, HVs responded slightly, but non-significantly, more accurately than schizophrenia patients. HVs, but not schizophrenia patients, exhibited greater cortical responses to attended visual changes. Bayesian model comparison revealed that a DCM with attention dependent changes in both top-down and bottom-up connections best explained responses by patients with schizophrenia, while in HVs the best model required only bottom-up changes. Quantitative comparison of connectivity estimates revealed a significant group difference in changes in the right IPS-TPJ connection: schizophrenia patients showed relative reductions in connectivity during attended stimulus changes. Crucially, this reduction predicted lower intelligence. These data are consistent with the hypothesis that functional dysconnections in the FPN contribute to cognitive impairment in schizophrenia.