The study on the frontoparietal networks by continuous theta burst stimulation in healthy human subjects
The study on the frontoparietal networks by continuous theta burst stimulation in healthy human subjects
复制标题
健康人类受试者持续θ爆发刺激额顶网络的研究
DOI：
10.1016/j.bbr.2012.11.015
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发表时间：
2013-03-01
影响因子：
2.7
通讯作者：
Pei, Zhong
中科院分区：
文献类型：
--
作者：
Xu, Guangqing;Lan, Yue;Pei, Zhong
额顶叶网络（FPN）包括后顶叶皮层（PPC）和背外侧前额叶皮层（DLPFC）区域，与视觉空间注意力有关。然而，背侧 FPN 不同区域之间的功能相互作用仍然难以捉摸。使用注意力网络测试（ANT）和连续θ爆发刺激（cTBS）来研究健康受试者的功能相互作用。在 ANT 任务期间，与接受假 cTBS 或左侧 PPC cTBS 的受试者相比，接受右侧 PPC cTBS 的受试者在空间提示条件下的反应明显较慢，警觉性和定向指数均存在缺陷。此外，与接受假 cTBS 的受试者相比，接受左 DLPFC cTBS 的受试者在警觉和冲突指数方面表现出显着改善，而在定向指数方面则显着缺乏。此外，与暴露于假cTBS条件的受试者相比，暴露于cTBS的受试者右侧DLPFC表现出警觉和冲突指数效率显着下降，而定向指数显着增加。此外，接受左 DLPFC-cTBS 的受试者和接受右 DLPFC-cTBS 的受试者之间的警觉、定向和冲突效应指数存在显着差异。这些结果表明，右侧 DLPFC 在执行控制过程中发挥着关键作用，而右侧 PPC 则与定向注意力功能相关。目前的研究不仅支持半球间视觉空间注意力竞争模型，而且还表明 FPN 不同区域之间存在区域间竞争。 (C) 2012 Elsevier B.V. 保留所有权利。
Frontoparietal networks (FPNs) including the regions of the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (DLPFC) have been implicated in visuospatial attention. However, the functional interactions among different regions of dorsal FPNs remain elusive. The Attention Network Test (ANT) and continuous theta burst stimulation (cTBS) were used to investigate the functional interactions in healthy subjects. During the ANT task, subjects receiving right PPC cTBS responded significantly slower in spatial cue condition, had deficits in both alerting and orienting indices compared with those receiving either the sham cTBS or left PPC cTBS. In addition, subjects receiving left-DLPFC cTBS showed significant improvements on alerting and conflict indices whereas significant deficits on the orienting index compared with those receiving the sham cTBS. Moreover, compared with subjects exposed to the sham cTBS condition, subjects exposed to cTBS to the right-DLPFC exhibited significant decreases in the efficiency of the alerting and conflict indices whereas significant increases in the orienting index. Furthermore, there were significant differences in the alerting, orienting and conflict effect indices between subjects receiving the left-DLPFC-cTBS and those receiving the right-DLPFC-cTBS. These results suggest that the right DLPFC played a pivotal role in executive control process, whereas the right PPC was associated with orienting attentional function. The current study not only supports the model of inter-hemispheric rivalry for visuospatial attention, but also indicates inter-regional competition between the different areas of the FPNs. (C) 2012 Elsevier B.V. All rights reserved.