Prenylated Flavonoids from the Roots of Desmodium caudatum and Evaluation of Their Antifungal Activity
Prenylated Flavonoids from the Roots of Desmodium caudatum and Evaluation of Their Antifungal Activity
复制标题
DOI：
10.1055/s-0032-1315391
复制
发表时间：
2012-11-01
期刊：
影响因子：
2.7
通讯作者：
Takaishi, Yoshihisa
中科院分区：
文献类型：
--
作者：
Sasaki, Hisako;Kashiwada, Yoshiki;Takaishi, Yoshihisa
从山蚂蝗（Desmodiumcaudatum）根中分离得到两个新的异戊烯化黄酮（1，4）和两个新的异戊烯化C-甲基黄酮（6，7），以及四个已知的黄酮（2，3，5，8）。新化合物的结构经1D-NMR、2D-NMR和MS等波谱分析确证。从该植物中分离得到的5个化合物（1，2，4，6，8）和9个黄酮类化合物（9-17）对黑曲霉（Aspergillus尼日尔）、青霉（Penicillium sp.）根霉属、和毛癣菌属。化合物6显示出对毛癣菌属的有效抗真菌活性，最小抑制浓度（MIC）值为1.95 μ g/mL。
Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities of five compounds (1, 2, 4, 6, 8) as well as nine flavonoids (9-17) previously isolated from this plant against Aspergillus niger, Penicillium sp., Rhizopus sp., and Trichophyton sp. were evaluated. Compound 6 showed potent antifungal activity against Trichophyton sp. with a minimum inhibitory concentration (MIC) value of 1.95 mu g/mL.