CATABOLISM AND INTERCONVERSION OF CORTISOL AND CORTISONE IN HUMAN SYNOVIAL TISSUE IN-VITRO
CATABOLISM AND INTERCONVERSION OF CORTISOL AND CORTISONE IN HUMAN SYNOVIAL TISSUE IN-VITRO
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DOI：
10.1136/ard.28.6.637
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发表时间：
1969-01-01
影响因子：
27.4
通讯作者：
WEST, HF
中科院分区：
文献类型：
--
作者：
MURPHY, D;WEST, HF
本研究的目的是了解皮质醇和可的松是否在人类风湿滑膜组织中相互转化和分解代谢，并鉴定分解代谢产物。类风湿和非类风湿滑膜组织没有正式的比较，但是已经获得了足够的证据来证明这样的研究是正确的。肝外组织能够在体外代谢皮质醇已经被许多作者证明，但这与体内事件的相关性一直存在疑问，因为通常认为皮质醇几乎完全在肝脏中代谢。Murphy和West（1964）从间接证据推断出这种假设是不正确的，现在Bailey和West（1969）证实了这一点，并表明在正常情况下，是肝外组织主要负责皮质醇和可的松的相互转化和分解代谢。因此，以往的体外研究和本文的研究都与生理和病理过程密切相关。局部组织的皮质醇有效浓度可能低于正常水平，这可能会降低溶酶体的稳定性。这种情况在某些情况下可能是有利的，而在另一些情况下则相反。
The object of this study has been to find out whether cortisol and cortisone are interconverted and catabolized in human rheumatoid synovial tissue and to identify the catabolites. No formal comparison of rheumatoid and non-rheumatoid synovial tissue has been made, but sufficient evidence has been obtained to justify such a study. That extra-hepatic tissues are able to metabolize cortisol in vitro has been demonstrated by very many authors, butthe relevance of this to events in vivo has been in doubt as it has been generally assumed that cortisol is almost entirely metabolized in the liver. From in-direct evidence Murphy and West (1964) deduced that this assumption was incorrect, and now Bailey and West (1969) have confirmed this and have shown that under normal conditions it is the extra-hepatic tissues that are mainly responsible for the interconversion and catabolism of cortisoland cortisone. Hence the past studiesin vitro and those of this paper are very relevant to physiological and pathological processes. It ispossible thata local-ized tissue could have a subnormal effective con-centration of cortisol that would, among other things, reduce the stability of lysosomes. Such a state of affairs might be advantageous in some circumstances and the reverse in others.